SRP6087

AKR1C1 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Synonyme(s) : 20-alpha HSD, Aldo-keto reductase family 1 member C1, DD1/DD2, DDH1, HBAB
• Numéro CAS: 1527538-64-2
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Produit recombinant: expressed in E. coli
• Essai: ≥90% (SDS-PAGE)
• Forme: liquid
• Poids mol.: 38.9 kDa
• Conditionnement: pkg of 100 μg
• Numéro d'accès NCBI: Q04828
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... AKR1C1(1645)

Description

Description générale

AKR1C1 (aldo-keto reductase 1C1) is one of the four isoforms (AKR1C1–AKR1C4) of the phase I drug-metabolizing enzyme family called AKR1C.[1][2] This enzyme is thought to be composed of 323 amino acids, and its mRNA is expressed in brain, mammary gland tissues, liver, adrenal, prostate, uterus and testis.[3]

Actions biochimiques/physiologiques

AKR1C (aldo-keto reductase 1C) family of proteins is responsible for maintaining steroid homeostasis, activation of polycyclic aromatic hydrocarbons and the metabolism of prostaglandin. These enzymes function as NAD(P)(H)-dependent oxidoreductases and are responsible for the production of alcohol by catalyzing the reduction of aldehydes and ketones. Studies show that up-regulation of AKR1C1 is linked with resistance to anti-cancer therapeutics such as, adriamycin, daunorubicin and cisplatin.[1] In human endometrial tissues, this protein is responsible for the conversion of progesterone to a biologically inactive metabolite. Studies in cultured endometrial stromal cells show that the mRNA expression level of AKR1C1 is inversely dependent on the level of progesterone, thus suggesting that progesterone controls its own local concentration through AKR1C1 enzyme in endometrial stromal cells at peri-implantation periods.[4]

Forme physique

0.5 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 20% glycerol.

Notes préparatoires

Centrifuge the vial prior to opening.

Autres remarques

MGSSHHHHHH SSGLVPRGSH MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN RNVRYLTLDI FAGPPNYPFS DEY

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319
• Conseils de prudence: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable