SRP2142

RARβ, ligand binding domain (173-409), GST tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• Synonyme(s) : HAP, NR1B2, RRB2
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.26

Propriétés

• Source biologique: human
• Produit recombinant: expressed in E. coli
• Pureté: ≥80% (SDS-PAGE)
• Forme: frozen liquid
• Poids mol.: ~53.3 kDa
• Conditionnement: pkg of 10 μg
• Conditions de stockage: avoid repeated freeze/thaw cycles
• Concentration: 450 μg/mL
• Technique(s): ligand binding assay: suitable
• Couleur: clear colorless
• Numéro d'accès NCBI: NM_000965
• Numéro d'accès UniProt: P10826
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... RARB(5915)

Description

Actions biochimiques/physiologiques

Several members of nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; estrogen receptor-alpha (ER alpha) in breast cancer, androgen receptor (AR) in prostate cancer, and retinoic acid receptor α (RARα) in acute promyelocytic leukemia. Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), that each consists of three isotypes (α, β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, so-called retinoic acid response elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. The retinoic acid receptor alpha gene is the target of chromosomal rearrangements in all cases of acute promyelocytic leukemia (APL). RAR α is a negative regulator of promyelocyte differentiation when not complexed with RA, and stimulates this differentiation when bound to RA.

Forme physique

Clear and colorless frozen liquid solution

Notes préparatoires

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable