SML3123

NButGT

≥98% (HPLC)

• Synonyme(s) : (3aR,5R,6S,7R,7aR)-3a,6,7,7a-Tetrahydro-5-(hydroxymethyl)-2-propyl-5H-pyrano[3,2-d]thiazole-6,7-diol
• Formule empirique (notation de Hill): C₁₀H₁₇NO₄S
• Numéro CAS: 863918-55-2
• Poids moléculaire : 247.31
• Code UNSPSC : 41106609
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: -10 to -25°C
• Chaîne SMILES: CCCC1=N[C@@H]2[C@H]([C@@H]([C@H](O[C@@H]2S1)CO)O)O

Description

Actions biochimiques/physiologiques

NButGT is a potent and selective inhibitor of O-GlcNAcase (OGA), which elevates O-GlcNAc levels but does not cause insulin resistance in 3T3-L1 adipocytes, and in rats and mice. NButGT does not perturbed glucohomeostasis when used for extended time in rats and mice. NButGT attenuates the accumulation of Aβ, neuroinflammation, and memory in in a mouse model of Alzheimer’s disease. NButGT efficiently increased total O-GlcNAc, improves cardiovascular function and reduced animal mortality in rat model of sepsis.

Specific and potent inhibitor of O-GlcNAcase (OGA)

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable