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SML3068

Sigma-Aldrich

PSEM308 hydrochloride

≥98% (HPLC)

Synonyme(s) :

5-Methyl-3,4,14-triazapentacyclo[12.2.2.14,7.02,13.011,19]nonadeca-2,7(19),8,10-tetraene hydrochloride, 5-Methyl-5,8,9,10,11a,12-hexahydro-4H-8,11-ethanopyrido[3′,2′:3,4]diazepino[6,7,1-hi]indole hydrochloride, PSEM 308 hydrochloride, PSEM308 hydrochloride, Pharmacologically selective effector molecule 308, hydrochloride

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About This Item

Formule empirique (notation de Hill):
C17H21N3 · HCl
Poids moléculaire :
303.83
Numéro MDL:
MFCD31689250
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Conditions de stockage

desiccated

Couleur

white to beige

Solubilité

DMSO: 2 mg/mL, clear (warmed)

Température de stockage

2-8°C

Chaîne SMILES 

CC1CC2=CC=CC3=C2N1N=C(C4CCN5CC4)C5C3.Cl

Actions biochimiques/physiologiques

SEM308 is a pharmacologically selective effector molecule (PSEM) that acts as a selective agonist in vitro and in vivo for chimeric pharmacologically selective actuator modules (PSAMs) composed of nAChR α7 ligand-binding domain (LBD) with L141F or L141F/Y115F mutation fused to the ion pore domain (IPD) of a ligand-gated ion channel (LGIC), including glycine receptor (PSAML141F-GlyR & PSAML141F/Y115F-GlyR) and 5-HT3 (PSAML141F/Y115F-5-HT3).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Maria Soledad Esposito et al.
Nature, 508(7496), 351-356 (2014-02-04)
Translating the behavioural output of the nervous system into movement involves interaction between brain and spinal cord. The brainstem provides an essential bridge between the two structures, but circuit-level organization and function of this intermediary system remain poorly understood. Here
Kajana Satkunendrarajah et al.
Nature, 562(7727), 419-422 (2018-10-12)
Dysfunctional breathing is the main cause of morbidity and mortality after traumatic injury of the cervical spinal cord1,2 and often necessitates assisted ventilation, thus stressing the need to develop strategies to restore breathing. Cervical interneurons that form synapses on phrenic
Matthew Lovett-Barron et al.
Nature neuroscience, 15(3), 423-430 (2012-01-17)
Transforming synaptic input into action potential output is a fundamental function of neurons. The pattern of action potential output from principal cells of the mammalian hippocampus encodes spatial and nonspatial information, but the cellular and circuit mechanisms by which neurons
Akila Chandrasekar et al.
Cerebral cortex (New York, N.Y. : 1991), 29(6), 2701-2715 (2018-07-10)
Excessive excitation has been hypothesized to subsume a significant part of the acute damage occurring after traumatic brain injury (TBI). However, reduced neuronal excitability, loss of neuronal firing, and a disturbed excitation/inhibition balance have been detected. Parvalbumin (PV) interneurons are
Nai-Wen Tien et al.
Neuron, 94(3), 656-665 (2017-05-02)
Convergent input from different presynaptic partners shapes the responses of postsynaptic neurons. Whether developing postsynaptic neurons establish connections with each presynaptic partner independently or balance inputs to attain specific responses is unclear. Retinal ganglion cells (RGCs) receive convergent input from
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