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SML2896

Sigma-Aldrich

ONO-2506

≥98% (HPLC)

Synonyme(s) :

(-)-(2R)-2-Propyloctanoic acid, (2R)-2-Propyloctanoic acid, (R)-(-)-2-Propyloctanoic acid, (R)-2-Propyloctanoic acid, Arundic acid, ONO 2506, ONO2506

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About This Item

Formule empirique (notation de Hill):
C11H22O2
Numéro CAS:
185517-21-9
Poids moléculaire :
186.29
Numéro MDL:
MFCD08458423
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

oil

Couleur

colorless to yellow

Température de stockage

−20°C

InChI

1S/C11H22O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h10H,3-9H2,1-2H3,(H,12,13)/t10-/m1/s1

Clé InChI

YCYMCMYLORLIJX-SNVBAGLBSA-N

Actions biochimiques/physiologiques

ONO-2506 (arundic acid; (R)-2-propyloctanoic acid) is an inhibitory astrocytes-modulating agent that exerts glioprotective effects against amyloid-β-peptide (Aβ)-induced glial death in astrocyte cultures (50 μM ONO-2506 against 200 μM Aβ25-35, 24 hr; 1321N1 astrocytes) by decreasing both the intracellular and extracellular S100B levels. Blockade of astrocytic activation by ONO-2506 in vivo is shown to offer therapeutic efficacy in animal models of normal tension glaucoma (10 mg/kg po. mice), spinal cord injury (20 mg/kg/d ip or iv rats), brain seizure, ischemic stroke (10 mg/kg/d ip or iv rats), and Parkinson′s disease (30 mg/kg ip mice).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Mojtaba Keshavarz et al.
Iranian journal of basic medical sciences, 22(5), 557-562 (2019-06-21)
Valproic and arundic acids are astrocytes-modulating agents with potential effects in the treatment of Alzheimer's disease (AD). S100B is an astrocytic cytokine with a possible role in the pathogenesis of AD. In this study, we aimed to assess the glioprotective
Isato Fukushi et al.
Respiratory physiology & neurobiology, 226, 24-29 (2015-11-26)
Mild hypoxia increases ventilation, but severe hypoxia depresses it. The mechanism of hypoxic ventilatory depression, in particular, the functional role of the cerebrum, is not fully understood. Recent progress in glial physiology has provided evidence that astrocytes play active roles
Narito Tateishi et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 22(6), 723-734 (2002-06-05)
A novel agent, (R)-(-)-2-propyloctanoic acid (ONO-2506), has a unique property in that it modulates functions of activated cultured astrocytes, including pronounced inhibition of S-100beta synthesis. The present study examined whether administration of this agent would mitigate the delayed expansion of
Mitsuru Hanada et al.
Journal of the neurological sciences, 337(1-2), 186-192 (2013-12-24)
Arundic acid (ONO-2506) inhibits the production and release of S100 protein from astrocytes. While numerous studies have assessed the effect of ONO-2506 in the diseased brain, to the best of our knowledge, no study has examined the effect of ONO-2506
Pratap Karki et al.
Molecular neurobiology, 55(6), 5031-5046 (2017-08-16)
Glutamate is the major excitatory neurotransmitter in the brain, but excessive synaptic glutamate must be removed to prevent excitotoxic injury and death. Two astrocytic glutamate transporters, excitatory amino acid transporter (EAAT) 1 and 2, play a major role in eliminating
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