SML2560

OB-1

≥98% (HPLC)

• Synonyme(s) : Ethyl 5-(1-methyl-4-nitro-1H-imidazol-5-yloxy)-2-phenylbenzofuran-3-carboxylate
• Formule empirique (notation de Hill) : C₂₁H₁₇N₃O₆
• Numéro CAS: 300803-69-4
• Poids moléculaire : 407.38
• Numéro MDL: MFCD01462999
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to very dark brown
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: [N+](=O)([O-])c1nc[n](c1Oc2cc3c([o]c(c3C(=O)OCC)c4ccccc4)cc2)C
• Clé InChI: UJHGRDVYTTVJFD-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Inhibitor of Stomatin-like protein-3 (STOML3) oligomerization

OB-1 is an inhibitor of the oligomerization of Stomatin-like protein-3 (STOML3), which is a modulator of the mechanosensitive ion channel Piezo2. STOML3 requires oligomerization for its role as an endogenous regulator of the sensitivity of mechanosensitive Piezo ion channels in sensory neurons. By inhibiting this activity, OB-1 has been shown to reduce touch-evoked pain behavior in two mouse models of neuropathic pain.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable