SML1628

LMT-28

≥98% (HPLC)

• Synonyme(s) : (4S)-3-[(2S,3S)-3-Hydroxy-2-methyl-4-methylene-1-oxononyl]-4-(1-methylethyl)-2-oxazolidinone
• Formule empirique (notation de Hill): C₁₇H₂₉NO₄
• Numéro CAS: 1239600-18-0
• Poids moléculaire : 311.42
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825512
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: oil
• Couleur: colorless to light yellow, oil
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: CC(C)[C@H](N1C([C@@H](C)[C@H](O)C(CCCCC)=C)=O)COC1=O
• InChI: 1S/C17H29NO4/c1-6-7-8-9-12(4)15(19)13(5)16(20)18-14(11(2)3)10-22-17(18)21/h11,13-15,19H,4,6-10H2,1-3,5H3/t13-,14+,15+/m0/s1
• Clé InChI: UDXWSYOXIRPYFK-RRFJBIMHSA-N

Description

Actions biochimiques/physiologiques

LMT-28 is a derivative of oxazolidinone. It has the ability to repress the activation of signal transducer and activator of transcription 3 (STAT3) stimulated by interleukin 6 (IL-6). Orally administered LMT-28 reduced arthritis and acute pancreatitis stimulated by collagen in mice pathologic models.

LMT-28 is an IL-6 antagonist that targets the IL-6 Receptor β subunit, Glycoprotein 130 (gp130). Its binding to gp130) results in inhibition of IL-6 activation, and downregulation of levels of p-STAT3. LMT-28 was shown to stimulate phosphorylation of STAT3 and JAK2 protein. IL-6 dysregulation is involved in inflammation and cancers. LMT-28 had inhbitory activity against IL-6–dependent TF-1 cell proliferation and also had therapeutic effect against pancreatitis.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3