SML1148

YIL-781 hydrochloride

≥98% (HPLC)

• Synonyme(s) : 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride
• Formule empirique (notation de Hill) : C₂₄H₂₈FN₃O₂ · xHCl
• Numéro CAS: 875258-85-8
• Poids moléculaire : 409.50 (free base basis)
• Numéro MDL: MFCD19690924
• Code UNSPSC : 51111800
• ID de substance PubChem : 329825682
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: , white to yellow to light brown
• Solubilité: H₂O: 2 mg/mL, clear (warmed)
• Température de stockage: room temp
• Chaîne SMILES: CC(C)N(CCC1)C[C@H]1CN(C(C)=N2)C(C3=C2C=CC(OC4=CC=C(F)C=C4)=C3)=O.Cl
• InChI: 1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20;/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3;1H/t18-;/m0./s1
• Clé InChI: QQGRMONBDBMLSP-FERBBOLQSA-N

Description

Application

YIL-781 has been used as a ghrelin receptor (GHSR) antagonist in combination with methanandamide (mAEA) to study its effect on gastric vagal afferent mechanosensitivity.[1]

Actions biochimiques/physiologiques

YIL-781 is a Ghrelin receptor antagonist.

YIL-781 is a potent antagonist (Ki = 17 nM) of the growth hormone secretagogue receptor (GHS-R1). YIL-781 blocks ghrelin-induced reduction of insulin secretion in rat islets. In vivo, the compound YIL-781 improves glucose tolerance and reduces weight gain.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable