Monopolar spindle 1 (Mps1) protein contains a TPR (tetratricopeptide repeat) motif at its N-terminal and a C-terminal kinase domain.[1]
Application
Mps1-IN-3 has been used in 2D-proliferation and 3D-organotypic culture outgrowth assays.[2]
Actions biochimiques/physiologiques
Mps1 mediates phosphorylation of kinetochore scaffold 1.[1]
Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1, also known as TTK), a Dual-specificity kinase required for spindle pole body duplication and spindle checkpoint function. Mps1-IN-3 inhibited Mps1 kinase activity with an IC50 value of 50 nM inhibited the proliferation of U251 glioblastoma cells as determined by cell counting with an IC50 value of approximately 5 μM, and sensitized glioblastoma cells to vincristine in orthotopic mouse models.
Mps1-IN-3 is an inhibitor of Monopolar spindle 1 (MPS1.
Advances in Cancer Drug Targets: Volume: 2, 61-61 (2014)
Mutant p53 dictates the oncogenic activity of c-Abl in triple-negative breast cancers.
Morrison C D, et al.
Cell Death & Disease, 8(6), e2899-e2899 (2017)
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