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SML0806

7DG

Name: 7DG
Brand: SIGMA

≥95% (HPLC)

Synonyme(s) :

7-Desacetoxy-6,7-dehydrogedunin

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₆H₃₀O₅

Numéro CAS:

26927-01-5

Poids moléculaire :

422.51

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥95% (HPLC)

Form:

powder

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Propriétés

Quality Segment

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear

shipped in

wet ice

storage temp.

2-8°C

Description

General description

7-Desacetoxy-6,7-dehydrogedunin (7DG) is structurally similar to HSP90 (heat shock protein 90) inhibitor, also known as gedunin.[1]

Biochem/physiol Actions

7-Desacetoxy-6,7-dehydrogedunin (7DG) is a selective inhibitor of protein kinase R (PKR).

7-Desacetoxy-6,7-dehydrogedunin (7DG) is a selective inhibitor of protein kinase R (PKR). 7DG appears to directly interact with the C-terminal half of PKR, and unlike C16, does not bind the ATP catalytic pocket. 7-Desacetoxy-6,7-dehydrogedunin completely protected macrophages from anthrax lethal toxin (LT)-induced pyroptotic cell death, a model for inflammasome-mediated caspase-1 activation, with an (IC₅₀) of 5 μM, showing a role for PKR in pyroptosis.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Cet article	361549	521234	288104
Sigma-Aldrich SML0806 7DG	Sigma-Aldrich 361549 GSK-3β Inhibitor VIII	Sigma-Aldrich 521234 PDGFR Tyrosine Kinase Inhibitor V	Sigma-Aldrich 288104 2′,5′-Dideoxyadenosine
description ≥95% (HPLC)	description The GSK-3β Inhibitor VIII, also referenced under CAS 487021-52-3, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description The PDGFR Tyrosine Kinase Inhibitor V, also referenced under CAS 347155-76-4, controls the biological activity of PDGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description Cell-permeable, non-competitive adenylate cyclase inhibitor (IC50 = 3 µM), that binds to the adenosine P1 binding site.
form powder	form solid	form solid	form solid
assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 5 mg/mL, clear	solubility DMSO: 5 mg/mL	solubility DMSO: 25 mg/mL	solubility DMSO: 10 mg/mL
color white to beige	color yellow	color off-white	color white

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Principaux documents

Passer à

7DG

≥95% (HPLC)

A propos de cet article

Quality Segment

assay

form

color

solubility

shipped in

storage temp.

General description

Biochem/physiol Actions

Features and Benefits

Comparer avec des articles similaires

Cet article

Informations sur la sécurité

pictograms

signalword

hcodes

pcodes

Hazard Classifications

Classe de stockage

wgk

flash_point_f

flash_point_c

Documentation

Certificats d'analyse (COA)

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