SML0213

MC2050 hydrate

≥98% (HPLC)

• Synonyme(s) : 2-[2-(4-(2-pyridyl)-1-piperazinyl)ethylsulfanyl]-3H-quinazolin-4-one dihydrochloride hydrate
• Formule empirique (notation de Hill) : C₁₉H₂₁N₅OS·2HCl · xH₂O
• Poids moléculaire : 440.39 (anhydrous basis)
• Numéro MDL: MFCD21608523
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825234
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: H₂O: ≥5 mg/mL at warmed to 60 °C
• Température de stockage: 2-8°C
• Chaîne SMILES: O.Cl.Cl.O=C1NC(SCCN2CCN(CC2)c3ccccn3)=Nc4ccccc14
• InChI: 1S/C19H21N5OS.2ClH.H2O/c25-18-15-5-1-2-6-16(15)21-19(22-18)26-14-13-23-9-11-24(12-10-23)17-7-3-4-8-20-17;;;/h1-8H,9-14H2,(H,21,22,25);2*1H;1H2
• Clé InChI: LMZZPRHHBPFDGE-UHFFFAOYSA-N

Description

Application

MC2050 hydrate may be used in cell signaling studies.

Actions biochimiques/physiologiques

MC2050 is a PARP-1 inhibitor

MC2050 is a water-soluble PARP-1 inhibitor. The IC₅₀ for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells.

Caractéristiques et avantages

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable