SBR00088

Rilpivirine

≥95% (HPLC), powder

• Synonyme(s) : 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, R 278474, TMC 278
• Formule empirique (notation de Hill): C₂₂H₁₈N₆
• Numéro CAS: 500287-72-9
• Poids moléculaire : 366.42
• Numéro MDL: MFCD11046372
• Code UNSPSC : 51101500

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: powder
• Couleur: white to yellow, or beige
• Spectre d'activité de l'antibiotique: viruses
• Mode d’action: enzyme | inhibits
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N
• InChI: 1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+
• Clé InChI: YIBOMRUWOWDFLG-ONEGZZNKSA-N

Description

Description générale

Rilpivirine is an antibiotic which belongs to the class of compounds known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Actions biochimiques/physiologiques

Rilpivirine inhibits the activity of the reverse transcriptase enzyme, which is essential for the replication of HIV-1. Specifically, it binds to a specific site on the enzyme and blocks its activity, thereby preventing the conversion of viral RNA into DNA, which is an essential step for the integration of viral DNA into host cells.

Rilpivirine is a next generation nonnucleoside reverse transcriptase inhibitor (NNRTI), It has been shown to be active against many HIV strains with mutations that confer resistance to the first-generation NNRTIs.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable