SAB4700455
Monoclonal Anti-CD140a-APC antibody produced in mouse
clone 16A1, purified immunoglobulin, buffered aqueous solution
Synonyme(s) :
Anti-PDGF-RA, Anti-PDGFRA
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Conjugué
Allophycocyanin conjugate
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
16A1, monoclonal
Forme
buffered aqueous solution
Espèces réactives
human
Technique(s)
flow cytometry: suitable
Isotype
IgG1
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... PDGFRA(5156)
Catégories apparentées
Description générale
Cluster of differentiation 140a (CD140a), also known as platelet-derived growth factor receptor α(PDGFRA), is encoded by the gene mapped to human chromosome 4q12. The encoded protein belongs to the receptor tyrosine kinase gene family.
The mouse monoclonal antibody 16A1 recognizes CD140a / PDGF-RA, the 170 kDa alpha chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative or anti-proliferative roles in various tumours.
Immunogène
CD140a-transfected NIH 3T3 cells
Application
The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (0.25 mL) is sufficient for 25 tests.
Actions biochimiques/physiologiques
Platelet-derived growth factor receptor plays a vital role in the development and maturation of platelets. Cluster of differentiation 140a (CD140a)/ PDGFRA acts as a potential target of for imatinib, a revolutionary drug for the treatment of chronic myeloid leukemia. PDGFRA pathway might be involved in developmental process of thrombocytes. The encoded protein facilitates hepatic stellate cell (HSCs) proliferation and migration. Mutation in the gene has been observed in gastrointestinal stromal tumors (GISTs).
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forme physique
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Platelet-Derived Growth Factor Receptor α Contributes to Human Hepatic Stellate Cell Proliferation and Migration.
Kikuchi A, et al.
The American Journal of Pathology, 187 (2017)
A 1.8-Mb YAC contig spanning three members of the receptor tyrosine kinase gene family (Pdgfra, Kit, and Flk1) on mouse chromosome 5
Brunkow ME, et al.
Genomics, 25 (1995)
PDGFRα promoter polymorphisms and expression patterns influence risk of development of imatinib-induced thrombocytopenia in chronic myeloid leukemia: A study from India
Guru SA, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39 (2017)
PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib.
Corless CL, et al.
Journal of Clinical Oncology, 23, 5357-5364 (2005)
Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.
Saigusa K, et al.
Cancer Science, 96, 676-676 (2005)
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