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SAB4504621

Sigma-Aldrich

Anti-phospho-MER/SKY (pTyr749/681) antibody produced in rabbit

affinity isolated antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 110 kDa

Espèces réactives

human, rat, mouse

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

Q06418
Q12866

Numéro d'accès UniProt

Q06418

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pTyr749/pTyr681)

Informations sur le gène

human ... MERTK(10461) , TYRO3(7301)

Description générale

Tyro3 (TYRO3 protein tyrosine kinase) is an 890 amino acid protein that belongs to the TAM (Tyro3, Axl and Mer) receptor family. Tyro3 is mapped to human chromosome 15q15. It is highly expressed in the nervous system like the neocortex, hippocampus and cerebellum. It is also present in monocytes, macrophages, platelets, dendritic cells and NK cells, breast, ovary, testis, lung, kidney, retinal pigment epithelium and osteoclasts.

Immunogène

The antiserum was produced against synthesized peptide derived from human MER/SKY around the phosphorylation site of Tyr749/681.

Immunogen Range: 716-765

Actions biochimiques/physiologiques

Tyro3 (TYRO3 protein tyrosine kinase) serves as a therapeutic target in breast cancer. This protein is involved in spermatogenesis, immunoregulation, and phagocytosis. It controls disseminated prostate cancer cellular dormancy. TYRO3 helps in the survival and transport of of gonadotropin-releasing hormone (GnRH) neurons within the forebrain. Mutation in TYRO3 result in retinitis pigmentosa.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

A novel MERTK mutation causing retinitis pigmentosa.
Al-Khersan H, et al.
Graefe'S Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 255(8), 1613-1619 (2017)
Ligand Recognition and Homophilic Interactions in Tyro3 STRUCTURAL INSIGHTS INTO THE Axl/Tyro3 RECEPTOR TYROSINE KINASE FAMILY.
Heiring C, et al.
The Journal of Biological Chemistry, 279(8), 6952-6958 (2004)
Mer tyrosine kinase regulates disseminated prostate cancer cellular dormancy.
Cackowski FC, et al.
Journal of Cellular Biochemistry, 118(4), 891-902 (2017)
Nour Al Kafri et al.
Biochemistry and biophysics reports, 30, 101263-101263 (2022-05-07)
The homologous proteins Gas6 and protein S (ProS1) are both natural ligands for the TAM (Tyro3, Axl, MerTK) receptor tyrosine kinases. ProS1 selectively activates Tyro3; however, the precise molecular interface of the ProS1-Tyro3 contact has not been characterised. We used
TYRO3 as a potential therapeutic target in breast cancer.
Ekyalongo RC, et al.
Anticancer Research, 34(7), 3337-3345 (2014)
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