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SAB4503376

Sigma-Aldrich

Anti-GPR174 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

FKSG79, GPR174, Probable G-protein coupled receptor 174

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.43

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 38 kDa

Espèces réactives

human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:40000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

Numéro d'accès NCBI

Q9BXC1

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... GP174(84636)

Description générale

G protein-coupled receptor 174 (GPR174) is a 333 amino acid protein encoded by the gene with one exon mapped to human chromosome Xq21.1. GPR174 is a member of G protein–coupled receptor 1(GPCR1) / rhodopsin-like family. The encoded protein consists of seven α -helical transmembrane domains. The protein is predominantly expressed in immune related tissues, and it is expressed at low levels in thyroid.

Immunogène

The antiserum was produced against synthesized peptide derived from human GPR174.

Immunogen Range: 131-180

Actions biochimiques/physiologiques

G protein-coupled receptor 174 (GPR174) plays a vital role in inducing signal transduction in immune cells. GPR174 upon lysophosphatidylserine (LysoPS) binding, enhances the production of intracellular cyclic adenosine monophosphate (cAMP) in a dose dependent manner. Mutation in GPR174 gene can be a risk factor for Graves′ disease (GD) and autoimmune addison′s disease (AAD). Upregulation of intracellular cAMP by GPR174 leads to the inhibition of immune cell proliferation. GPR174, as a LysoPS receptor, might play a crucial role in the central nervous system. Alteration in the expression of the gene results in vasovagal syncope (VVS). Overexpression of GPR174 is observed in subcutaneous metastases. Lysophosphatidylserine (LysoPS) secreted by the immune system in vivo, acts as a ligand for GPR174.

Caractéristiques et avantages

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Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves' disease.
Chu X, et al.
Journal of medical Genetics, 50(7), 479-485 (2013)
Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.
Huang YJ, et al.
Pediatric Cardiology, 36(3), 475-480 (2015)
Role of the X-linked gene GPR174 in autoimmune Addison's disease.
Napier C, et al.
The Journal of Clinical Endocrinology and Metabolism, 100(1), E187-E190 (2015)
Y Qin et al.
Pigment cell & melanoma research, 24(1), 207-218 (2010-10-01)
G-protein-coupled receptors (GPCRs) have been implicated in the tumorigenesis and metastasis of human cancers and are considered amongst the most desirable targets for drug development. Utilizing a robust quantitative PCR array, we quantified expression of 94 human GPCRs, including 75

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