SAB4300689

Anti-ABCG2 antibody produced in rabbit

affinity isolated antibody

• Synonyme(s) : Anti-ABC15, Anti-ABCP, Anti-BMDP, Anti-CD338, Anti-MRX
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: 65-80 kDa
• Espèces réactives: human
• Concentration: 1 mg/mL
• Technique(s): western blot: 1:500-1:1000
• Isotype: IgG
• Séquence immunogène: (R-I-N-R-V)
• Numéro d'accès NCBI: NM_004827.2
• Numéro d'accès UniProt: Q9UNQ0
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... ABCG2(9429)

Description

Description générale

The ABCG2 (ATP binding cassette subfamily G member 2) gene encodes an ATP-binding cassette (ABC) transporter that is also called as breast cancer resistance protein (BRCP). It is composed of 655 amino-acids and is located on human chromosome 4q22. It belongs to the ABCG (white) subfamily.

The antibody detects endogenous level of total ABCG2(CD338) protein.

Immunogène

Peptide sequence around aa. 160-164 ( R-I-N-R-V), according to the protein NP_004818.2

Actions biochimiques/physiologiques

ABCG2 (ATP binding cassette subfamily G member 2) serves as a shield for several tissues against xenobiotic molecules. It can provide multidrug resistance (MDR) in breast and other cell lines.

Caractéristiques et avantages

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Description de la cible

Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable