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SAB4300121

Sigma-Aldrich

Anti-phospho-CHEK2 (pSer516) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-CDS1 antibody produced in rabbit, Anti-CHK2 antibody produced in rabbit, Anti-CHK2 checkpoint homolog (S. pombe) antibody produced in rabbit, Anti-HuCds1 antibody produced in rabbit, Anti-LFS2 antibody produced in rabbit

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

~62 kDa

Espèces réactives

human

Concentration

1 mg/mL

Technique(s)

western blot: 1:500-1:1000

Isotype

IgG

Séquence immunogène

(Q-P-SP-T-S)

Numéro d'accès NCBI

NP_001005735.1

Numéro d'accès UniProt

O96017

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pSer516)

Informations sur le gène

human ... CHEK2(11200)

Immunogène

Peptide sequence around phosphorylation site of serine 516 (Q-P-S(p)-T-S), according to the protein CHEK2.

Caractéristiques et avantages

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Description de la cible

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by Chk2 gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Helga B Landsverk et al.
Nucleic acids research, 47(4), 1797-1813 (2018-12-13)
Ataxia telangiectasia mutated and Rad3-related (ATR) kinase is a key factor activated by DNA damage and replication stress. An alternative pathway for ATR activation has been proposed to occur via stalled RNA polymerase II (RNAPII). However, how RNAPII might signal
Bo Liu et al.
The international journal of biochemistry & cell biology, 109, 40-58 (2019-02-03)
The role of protein phosphatase 2ACα (PP2ACα) in brain development is poorly understood. To understand the function of PP2ACα in neurogenesis, we inactivated Pp2acα gene in the central nervous system (CNS) of mice by Cre/LoxP system and generated the PP2ACα
Yuanxin Zhang et al.
Oncology letters, 18(2), 1881-1887 (2019-08-20)
Cervical cancer continues to be a threat to female health globally. In the present study, the potential anticancer activity of 2-[2-hydroxyl-1-(4-methoxy phenyl) ethyl]-3-(4-benzyloxy phenyl) isoindolin-1-one (CDS-1548), was evaluated in HeLa cells. CDS-1548 is an organic small-molecule compound characterized by two
Shiyuan Hong et al.
Oncogene, 38(17), 3274-3287 (2019-01-12)
High-risk human papillomaviruses (HPVs) constitutively activate ataxia telangiectasia mutated (ATM) and ataxia telangiectasia- and Rad3-related (ATR) DNA damage repair pathways for viral genome amplification. HPVs activate these pathways through the immune regulator STAT-5. For the ATR pathway, STAT-5 increases expression
Xingyi Guo et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 28(8), 1308-1315 (2019-06-05)
Pathogenic variants in susceptibility genes lead to increased breast cancer risk. To identify coding variants associated with breast cancer risk, we conducted whole-exome sequencing in genomic DNA samples from 831 breast cancer cases and 839 controls of Chinese women. We
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