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SAB4200652

Monoclonal Anti-TOM1L1 antibody produced in mouse

Name: Monoclonal Anti-TOM1L1 antibody produced in mouse
Brand: SIGMA

clone 3F12, purified from hybridoma cell culture

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About This Item

Code UNSPSC :

12352203

Source biologique

mouse

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

3F12, monoclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~53 kDa

Espèces réactives

human, bovine, monkey

Concentration

~1 mg/mL

Technique(s)

immunoblotting: 0.5-1 μg/mL using using whole extracts of HeLa cells.
immunofluorescence: 5-10 μg/mL using using HeLa cells.

Isotype

IgG1

Numéro d'accès UniProt

O75674

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TOM1L1(10040)

Description générale

The gene TOM1L1 (target of myb1 like 1 membrane trafficking) is mapped to human chromosome 17q23. The protein has a VHS (Vps27p/Hrs/Stam) domain at the N-terminal, a GAT (GGA (Golgi-localizing, γ-adaptin ear domain homology, ADP-ribosylation factor (Arf)-binding protein and Tom) domain at the center and interaction motifs at the C-terminal.

Immunogène

immunized with a TOM1L1 fusion protein.

Actions biochimiques/physiologiques

TOM1L1 (target of myb1 like 1 membrane trafficking) is an adaptor protein, which is involved in vesicular trafficking as well as intracellular signaling. It negatively controls the mitogenic and transforming functions in fibroblasts by working as a substrate for SRC (tyrosine protein kinase). It is involved in EGF (epidermal growth factor)-mediated internalization of EGF receptor. TOM1L1 is downregulated in cutaneous squamous cell carcinoma and esophageal squamous cell carcinoma.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

035M4836V

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

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Genomic and expression profiling of chromosome 17 in breast cancer reveals complex patterns of alterations and novel candidate genes.

Béatrice Orsetti et al.

Cancer research, 64(18), 6453-6460 (2004-09-18)

Chromosome 17 is severely rearranged in breast cancer. Whereas the short arm undergoes frequent losses, the long arm harbors complex combinations of gains and losses. In this work we present a comprehensive study of quantitative anomalies at chromosome 17 by

Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor.

Ning Sheng Liu et al.

The EMBO journal, 28(22), 3485-3499 (2009-10-03)

Although many proteins have been shown to participate in ligand-stimulated endocytosis of EGF receptor (EGFR), the adaptor protein responsible for interaction of activated EGFR with endocytic machinery remains elusive. We show here that EGF stimulates transient tyrosine phosphorylation of Tom1L1

TOM1L is involved in a novel signaling pathway important for the IL-2 production in Jurkat T cells stimulated by CD3/CD28 co-ligation.

Ahmed Elmarghani et al.

Mediators of inflammation, 2009, 416298-416298 (2010-02-26)

TOM1L (target of Myb-1 Like) was identified as a binding partner for the full length and catalytically-active Lck in a yeast 2-hybrid screening assay. Here we show that in Jurkat T cells stimulated by CD3/CD28 coligation where the expression of

Decreased Srcasm expression in esophageal squamous cell carcinoma in a Chinese population.

Yu Qi et al.

Anticancer research, 30(9), 3535-3539 (2010-10-15)

Src-family tyrosine kinases (SFKs) play critical roles in regulating cellular differentiation and proliferation. Src-activating and signaling molecule (Srcasm) is a novel molecule that down-regulates SFK activity and promotes cell differentiation. The aim of this study was to determine whether Srcasm

Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts.

Audrey Sirvent et al.

Molecular & cellular proteomics : MCP, 11(12), 1937-1950 (2012-10-02)

The non-receptor tyrosine kinase SRC is frequently deregulated in human colorectal cancer (CRC), and SRC increased activity has been associated with poor clinical outcomes. In nude mice engrafted with human CRC cells, SRC over-expression favors tumor growth and is accompanied

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