SAB4200439

Anti-EXOSC5 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonyme(s) : Anti-Exosome component 5, p12B, Anti-RRP41B, Anti-RRP46, Anti-Rrp46p, Anti-hRrp46p
• Code UNSPSC : 12352203

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen ~25 kDa
• Espèces réactives: human
• Concentration: ~1.0 mg/mL
• Technique(s): immunoprecipitation (IP): 1-2 μg using lysates of human HeLa cells.; indirect immunofluorescence: 1-2 μg/mL using human HeLa cells.; western blot: 1-2 μg/mL using whole extracts of human HEK-293T cells.
• Numéro d'accès UniProt: Q9NQT4
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... EXOSC5(56915)

Description

Description générale

Exosome component 5 (EXOSC5) protein is a non-catalytic element of the RNA exosome complex in eukaryotes. The EXOSC5 gene is located on the human chromosome at 19q13.2.

Spécificité

Anti-EXOSC5 (N-terminal) recognizes human EXOSC5.

Immunogène

peptide corresponding to the N-terminal region of human EXOSC5, conjugated to KLH. The antibody is affinity-purified using the immunizing peptide immobilized on agarose.

Application

Anti-EXOSC5 (N-terminal) antibody produced in rabbit may be used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

Actions biochimiques/physiologiques

Exosome component 5 (EXOSC5) plays a role in the processing and degradation of RNA. This protein also plays a role in cleaving the DNA during apoptosis. EXOSC5 possesses a 3′-5′ exoribonuclease activity. Overexpression of the EXOSC5 gene is associated with several cancers such as melanoma, prostate, colorectal and lung cancer.

Forme physique

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Stockage et stabilité

For continuous use, store at 2-8°C for up to one month. Forextended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable