SAB4200424

Anti-COG1 (C-TERMINAL) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonyme(s) : Anti-CDG2G, Anti-COG complex subunit 1, Anti-LDLB, Anti-component of oligomeric golgi complex 1, Anti-conserved oligomeric Golgi complex subunit 1, Anti-low density lipoprotein receptor defect
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 200
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen ~110 kDa
• Espèces réactives: mouse, human, rat
• Concentration: ~1.0 mg/mL
• Technique(s): indirect immunofluorescence: 1-2 μg/mL using human HeLa cells.; western blot: 2.5-5.0 μg/mL using whole extracts of mouse LA-4 cells.
• Numéro d'accès UniProt: Q8WTW3
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... COG1(9382) ; mouse ... Cog1(16834) ; rat ... Cog1(303652)

Description

Description générale

COG1 is a member of the conserved oligomeric Golgi (COG) complex. COG complex is an evolutionarily conserved multi-subunit protein complex. COG complex consists of eight distinct subunits organized in two heterotrimeric groups, Cog2-Cog3-Cog4 and Cog5-Cog6-Cog7, which are linked by the dimeric group formed by Cog1 and Cog8.

Conserved oligomeric Golgi (COG) subunit 1 is an essential component of the conserved oligomeric Golgi complex. It is encoded by the gene mapped to human chromosome 17q25.1.

Immunogène

peptide corresponding to the C-terminal region of human COG1, conjugated to KLH. The corresponding sequence is identical in mouse, rat and monkey COG1.

Application

Anti-COG1 (C-TERMINAL) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Actions biochimiques/physiologiques

COG1 is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates. It plays a role in the organization of the Golgi-localized complex. Mutations in COG1 in humans cause novel types of congenital disorders of glycosylation (CDG). COG complex regulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells.

Conserved oligomeric Golgi (COG) complex plays a vital role in retrograde vesicular trafficking and glycosylation.

Forme physique

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable