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SAB4200328

Sigma-Aldrich

Anti-acetyl-Histone H3 [Ac-Lys56]

IgG fraction of antiserum

Synonyme(s) :

Anti-H3.4, Anti-H3/g, Anti-H3FT, Anti-H3K56ac, Anti-H3t, Anti-HIST3H3

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About This Item

Code UNSPSC :
12352203

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~15 kDa

Espèces réactives

rat, human, mouse

Technique(s)

western blot: 1:1000-1:2000 using NIH3T3 or HeLa cell lysates

Numéro d'accès UniProt

Q16695

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

acetylation (Lys56)

Informations sur le gène

human ... HIST3H3(8290)

Description générale

Histones are considered as the important constituents of chromatin. They are classified into core histones and linker histones. Histone H3 gene codes for a H3 protein sequence. This H3 gene is located on human chromosome 1 (1q42).

Immunogène

synthetic peptide containing acetylated Lys56 of human histone H3, conjugated to KLH. The corresponding sequence is identical in many species including rat and mouse histone H3.

Application

Anti-acetyl-Histone H3 [Ac-Lys56] has been used in western blot analysis.

Actions biochimiques/physiologiques

Core histones and linker histones are known possesses inter and intra-specific amino acid sequence variability. Histone modifications are thought to play an important role in cancer and disease. Histones H3 and H4 are the predominant histones subjected to extensive covalent modifications. In human embryonic stem cells, histone H3 Lys56 acetylation is associated to the core transcriptional network.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells
Xie W, et al.
Molecular Cell, 33(4), 417-427 (2009)
A solitary human H3 histone gene on chromosome 1
Albig W, et al.
Human Genetics, 97(4), 486-491 (1996)
Depletion of cellular iron by curcumin leads to alteration in histone acetylation and degradation of Sml1p in Saccharomyces cerevisiae
Azad GK, et al.
PLoS ONE, 8(3), e59003-e59003 (2013)
Histone Variants: Signaling or Structural Modules
Handbook of Cell Signaling, 2409-2425 (2010)
Shraddha Chauhan et al.
Environmental science and pollution research international, 31(20), 30149-30162 (2024-04-11)
Nanoparticles, particularly magnesium oxide nanoparticles (MgO-NPs), are increasingly utilized in various fields, yet their potential impact on cellular systems remains a topic of concern. This study aimed to comprehensively investigate the molecular mechanisms underlying MgO-NP-induced cellular impairment in Saccharomyces cerevisiae
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