SAB4200282

Anti-TRIM2 (C-terminal region) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonyme(s) : Anti-Tripartite motif-containing protein 2, RNF86, Narf
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Espèces réactives: rat, human
• Validation améliorée: recombinant expression; Learn more about Antibody Enhanced Validation
• Concentration: ~1.0 mg/mL
• Technique(s): immunoprecipitation (IP): 5-10 μg using rat spinal cord extracts (S1 fraction); western blot: 1.5-3.0 μg/mL using MCF7 cell lysates
• Numéro d'accès UniProt: Q9C040
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Informations sur le gène: human ... TRIM2(23321) ; rat ... Trim2(361970)

Description

Description générale

Tripartite motif containing 2 (TRIM2) is an E3 ubiquitin ligase, encoded by the gene mapped to human chromosome 4q31.3. The encoded protein belongs to the TRIM– NCL-1, HT2A and Lin-41 (NHL) protein family. This 81kDa protein is characterized with an N-terminal really interesting new gene (RING) finger domain and a B-box domain, a middle coiled-coil domain and a C-terminal NHL domain.

Immunogène

synthetic peptide corresponding to a sequence located near the C-terminus of human TRIM2, conjugated to KLH. The corresponding sequence is identical in mouse and rat TRIM2.

Actions biochimiques/physiologiques

Tripartite motif containing 2 (TRIM2) ubiquitinates neurofilament light chain, B-cell lymphoma 2 (Bcl-2)-interacting mediator and motor protein myosin V. ) It has a role in polarization of neurons and outgrowth of axons. Loss of function of the protein has been linked to early-onset axonal neuropathy.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable