Accéder au contenu
Merck
Toutes les photos(3)

Documents

SAB4200178

Sigma-Aldrich

Anti-Importin 5 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Synonyme(s) :

Anti-IPO5, Anti-KPNB3, Anti-importin subunit beta-3, Anti-karyopherin beta-3

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(3)

About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~123 kDa

Espèces réactives

human

Concentration

~1.0 mg/mL

Technique(s)

immunoprecipitation (IP): 5-10 μg using lysates of human HEK-293T cells.
indirect immunofluorescence: 2.5-5.0 μg/mL using HEK-293T cells overexpressing human Importin 5.
western blot: 2-4 μg/mL using whole extracts of human Jurkat cells.

Numéro d'accès UniProt

O00410

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... IPO5(3843)

Description générale

Importin 5 (IPO5) is encoded by the gene mapped to human chromosome 13q32.2. The encoded protein belongs to the importin β family. It is primarily expressed in cytoplasm, specifically in the nuclear pore complex.

Application

Anti-Importin 5 (N-terminal) antibody produced in rabbit has been used in western blotting, immunoprecipitation and immunofluorescence.

Actions biochimiques/physiologiques

Importin 5 (IPO5) in association with nucleoside triphosphates and the small GTP binding protein Ran, facilitates migration of nuclear localization signal (NLS)-containing cargo from cytoplasm to nucleus. IPO5 also plays a vital role in apolipoprotein A-1 excretion and also helps in transport of lipids from peripheral tissues via reverse cholesterol transport pathway. Additionally, the encoded protein facilitates transport of ribosomal proteins and core histones into the nucleus. Mutation in the gene is associated with the development of schizophrenia.
Importin 5 (also known as IPO5, karyopherin β-3, importin subunit β-3, KPNB3 and RANBP5) has been identified as an importin for histones and proteins L23a, S7, and L5, and also to the PB1 subunit of the influenza A virus RNA-dependent RNA polymerase.

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Outil de sélection de produits.

Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Genome-Wide Association Study of Peripheral Arterial Disease in a Japanese Population.
Matsukura M
PLoS ONE, 10 (2015)
The full-length interleukin-33 (FLIL33)--importin-5 interaction does not regulate FLIL33's nuclear localization but controls its intracellular degradation.
Clerman A
The Journal of Biological Chemistry (2017)
Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5
Hutchinson EC, et al.
The Journal of General Virology, 92(8), 1859-1869 (2011)
Genetic and functional study of the IPO5 gene in schizophrenia.
Wang ZQ
Psychiatry Research, 187, 460-461 (2011)
Andrew Clerman et al.
The Journal of biological chemistry, 292(52), 21653-21661 (2017-11-12)
Human mature IL-33 is a member of the IL-1 family and a potent regulator of immunity through its pro-T helper cell 2 activity. Its precursor form, full-length interleukin-33 (FLIL33), is an intranuclear protein in many cell types, including fibroblasts, and
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique