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SAB2900288

Anti-TICAM1/TRIF (AB1) antibody produced in rabbit

Name: Anti-TICAM1/TRIF (AB1) antibody produced in rabbit
Brand: SIGMA

IgG fraction of antiserum, buffered aqueous solution

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About This Item

Code UNSPSC :

12352203

Nomenclature NACRES :

NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

Numéro d'accès UniProt

Q8IUC6

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TICAM1(148022)

Description générale

Toll like receptor adaptor molecule 1 (TICAM1) is ubiquitously expressed and possesses an N-terminal proline-rich domain, a TIR (Toll/interleukin-1 receptor) motif and a C-terminal proline-rich domain. The gene encoding this protein is localized on human chromosome 19p13.3.

Immunogène

Synthetic peptide from human TICAM1 / TRIF.

Actions biochimiques/physiologiques

Toll like receptor adaptor molecule 1 (TICAM1) plays a crucial role as an adaptor molecule and links toll-like receptor 3 (TLR3) to interferon-β (IFN-β) promoter activation. It is also involved in IFN-β production. TICAM-1 pathway has an essential role in host protection and innate immune responses against poliovirus (PV) infection. Mutations in the gene have been associated with the development of papillary thyroid cancer, follicular thyroid cancer and differentiated thyroid cancer.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Selected single-nucleotide polymorphisms in FOXE1, SERPINA5, FTO, EVPL, TICAM1 and SCARB1 are associated with papillary and follicular thyroid cancer risk: replication study in a German population.

Sigurdson AJ

Carcinogenesis (2016)

The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection.

Oshiumi H

Journal of Immunology (2011)

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.