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SAB2501087

Sigma-Aldrich

Anti-Uncoupling Protein 2/UCP2 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-SLC25A8, Anti-UCPH, Anti-Uncoupling protein 2

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

goat

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

mouse, rat

Technique(s)

immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable

Numéro d'accès UniProt

P70406

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... UCP2(7351)

Description générale

Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein. It expressed in various regions of the brain. In non-human primates, it is present in the hypothalamic nuclei, pituitary gland, brainstem, ventral tegmental area and substantia nigra. It is located on human chromosome 11q13.

Immunogène

Peptide with sequence C-DSVKQFYTKGSEH from the internal region of the protein sequence according to NP_003346.2.

Application

Anti-uncoupling protein 2/UCP2 antibody has been used in immunoblotting.

Actions biochimiques/physiologiques

Uncoupling protein 2 (UCP2) controls energy metabolism and decreases the production of reactive oxygen species and guards against reperfusion damage. It plays a vital role in uncoupling electron transport from adenosine triphosphate (ATP) formation.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults
Heise, et al.
PLoS ONE, 12(8), e0181392-e0181392 (2017)
Jelena Stevanović-Silva et al.
Metabolism: clinical and experimental, 116, 154704-154704 (2021-01-10)
Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life and in their offspring. In contrast, exercise is recognized as a non-pharmacological strategy against metabolic dysfunctions associated to lifestyle
Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto (mito) phagy markers
Marques A I, et al.
Neuroscience, 301(8), 480-495 (2015)
Uncoupling protein 2 region on chromosome 11q13 is not linked to markers of obesity in familial type 2 diabetes
Elbein S C, et al.
Diabetes, 46(12), 2105-2108 (1997)
The UCP2-866G/A Polymorphism Could be Considered as a Genetic Marker of Different Functional Prognosis in Ischemic Stroke After Recanalization
Cicuendez I D M, et al.
Neuromolecular Medicine, 19(4), 571-578 (2017)

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