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SAB2101106

Sigma-Aldrich

Anti-HTR2A antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-5-HT2A, Anti-5-hydroxytryptamine (serotonin) receptor 2A, Anti-HTR2

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

52 kDa

Espèces réactives

human

Concentration

0.5 mg - 1 mg/mL

Technique(s)

western blot: suitable

Numéro d'accès UniProt

P28223

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... HTR2A(3356)

Description générale

5-hydroxytryptamine receptor 2A (HTR2A) encodes for a G-Protein coupled serotonin receptor. HTR2A is predominantly expressed in the brain near to serotoninergic neurons. The gene HTR2A is localized on human chromosome on 13q14.2.

Immunogène

Synthetic peptide directed towards the N terminal region of human HTR2A

Actions biochimiques/physiologiques

5-hydroxytryptamine receptor 2A (HTR2A) binds to neurotransmitters or drugs and activates the G-protein coupled signalling pathway by stimulating phospholipase C signalling cascade and the ultimate release of calcium. and modulates cognitive functions, memory, learning etc. HTR2A is the drug targeting receptor for many of the antipsychotic drugs like serotonergic psychedelics. Genetic polymorphisms as well as epigenetic factors regulate the expression of HTR2A. These variations in the regulation lead to a wide variety of psychotic disorders like schizophrenia, mood disorders, attention deficit hyperactivity disorder, suicide, anxiety disorders, obsessive-compulsive disorder, eating disorders, and Alzheimer′s disease.

Séquence

Synthetic peptide located within the following region: DILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSEN

Forme physique

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression
Myers RL, et al.
Biological Psychiatry, 61(2), 167-173 (2007)
Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder
Abdolmaleky HM, et al.
Schizophrenia Research, 129(2-3), 183-190 (2011)
Functional selectivity and classical concepts of quantitative pharmacology
Urban JD, et al.
Journal of Pharmacology and Experimental Therapeutics, 320(1), 1-13 (2007)
The role of serotonin 5-HT2A receptors in memory and cognition
Zhang G and Stackman Jr RW
Frontiers in Pharmacology, 6, 225-225 (2015)
J F Quist et al.
Molecular psychiatry, 5(5), 537-541 (2000-10-14)
A recent study demonstrated that treatment of hyperactive mice with psychostimulants and serotonergic agents produced a calming effect that was dependent on serotonergic neurotransmission and was not associated with any changes in extracellular dopamine levels. The complex interaction between the
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