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S8647

Sigma-Aldrich

Sulfacetamide sodium salt monohydrate

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About This Item

Formule empirique (notation de Hill):
C8H9N2NaO3S · H2O
Numéro CAS:
6209-17-2
Poids moléculaire :
254.24
Numéro MDL:
MFCD00149555
Code UNSPSC :
51102829
ID de substance PubChem :
24899806
Nomenclature NACRES :
NA.85

Forme

powder

Couleur

white to off-white

Solubilité

H2O: soluble 50 mg/mL

Spectre d'activité de l'antibiotique

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

Mode d’action

DNA synthesis | interferes
enzyme | inhibits

Chaîne SMILES 

NC1=CC=C(S(N([Na])C(C)=O)(=O)=O)C=C1.O

InChI

1S/C8H10N2O3S.Na.H2O/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8;;/h2-5H,9H2,1H3,(H,10,11);;1H2/q;+1;/p-1

Clé InChI

IHCDKJZZFOUARO-UHFFFAOYSA-M

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Description générale

Chemical structure: sulfonamide

Actions biochimiques/physiologiques

Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Conditionnement

100G

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Margareta Ungureanu et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 110(2), 456-459 (2007-09-07)
In the present study we emphasized the antituberculosis action of new sulphacetamide derivatives. In order o extend the research for obtaining antituberculosis substances, we decided to study the influence of the introducing of the thiourea and sulphamide groups in the
Ilknur Akyol-Salman et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 28(1), 49-52 (2011-07-15)
This study aimed to compare the efficacy of topical N-acetyl-cysteine (NAC) with a topical steroid-antibiotic combination, betamethasone-sulfacetamide sodium therapy in patients with meibomian gland dysfunction (MGD). Twenty patients with MGD were prospectively randomized and assigned into 2 groups. The patients
M Gooderham
Skin therapy letter, 14(2), 1-3 (2009-03-31)
Many options exist for the treatment of rosacea, including topical and systemic therapies, laser and light-based therapies, and surgical procedures. A classification system for rosacea identifies 4 subtypes (i.e., erythematotelangiectatic, papulopustular, phymatous, and ocular), which may help guide therapeutic decision-making.
Zoe Diana Draelos
Journal of drugs in dermatology : JDD, 9(3), 234-236 (2010-03-18)
Prior to 1962, some of the most versatile drugs in dermatology were approved by the U.S. Food and Drug Administration (FDA) solely on the basis of safety. One of these is the combination 10% sodium sulfacetamide and 5% sulfur. Sodium
James Q Del Rosso
Cutis, 86(5 Suppl), 16-25 (2011-01-15)
Rosacea is a prevalent inflammatory skin disorder that affects approximately 16 million individuals in the United States. Although its exact etiology is unknown, basic science, histologic evidence, and clinical evidence suggest that it is inflammatory in nature. In this 12-week
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