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S8409

Superoxide Dismutase from bovine liver

Name: Superoxide Dismutase from bovine liver
Brand: SIGMA
Price: 45.4 EUR

ammonium sulfate suspension, 2,000-6,000 units/mg protein (biuret)

Synonyme(s) :

SOD, Superoxide: superoxide oxidoreductase

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Taille/Référence	Disponibilité	Prix
3000 units	Vérifier la disponibilité des articles du panier	45,40 €
15000 units	Vérifier la disponibilité des articles du panier	111,00 €
30000 units	Vérifier la disponibilité des articles du panier	203,00 €

A propos de cet article

Numéro CAS:

9054-89-1

UNSPSC Code:

12352204

NACRES:

NA.54

EC Number:

232-943-0

MDL number:

MFCD00132404

Numéro CE :

1.15.1.1 (BRENDA, IUBMB)

Specific activity:

2,000-6,000 units/mg protein (biuret)

45,40 €

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Propriétés

form

ammonium sulfate suspension

Quality Segment

200

specific activity

2,000-6,000 units/mg protein (biuret)

mol wt

32.5 kDa

UniProt accession no.

P00442

storage temp.

2-8°C

Gene Information

cow ... SOD1(281495)

Description

General description

Research area: Cell Signaling

Superoxide dismutases are a group of low molecular weight metalloproteins present in all aerobic cells of plants, animals, and micro-organisms. They provide protection against damaging reactions with the superoxide radical anion (O2-) by catalyzing its disproportionation into oxygen and hydrogen peroxide.

Application

Superoxide Dismutase from bovine liver has been used:

for measuring mitochondrial hydrogen peroxide production in skeletal muscle
as a positive control in Cu(II) binding stability assay
as a positive control in superoxide dismutase assay
in a study to assess the inactivation of endothelial-derived relaxing factor by oxidized lipoproteins.
in a study to investigate the role of hydrogen peroxide in the cytotoxicity of the xanthine/xanthine oxidase system.

Biochem/physiol Actions

Superoxide Dismutase catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. It plays a critical role in the defense of cells against the toxic effects of oxygen radicals. It competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby SOD promotes the activity of NO. SOD has also been shown to suppress apoptosis in cultured rat ovarian follicles, neural cell lines, and transgenic mice.

Physical form

Suspension in 3.8 M (NH₄)₂SO₄, pH 7.0

Analysis Note

For assay method, see McCord, J.M. and Fridovich,I., J. Biol. Chem., 244, 6049 (1969).

Other Notes

One unit will inhibit reduction of cytochrome c by 50% in a coupled system with xanthine oxidase at pH 7.8 at 25 °C in a 3.0 mL reaction volume. Xanthine oxidase concentration should produce an initial ΔA₅₅₀of 0.025 ± 0.005 per min.

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Cet article	S8160	S7446	G2501
Sigma-Aldrich S8409 Superoxide Dismutase from bovine liver	Sigma-Aldrich S8160 Superoxide Dismutase from bovine liver	Sigma-Aldrich S7446 Superoxide Dismutase from bovine erythrocytes	Sigma-Aldrich G2501 L-Glutamic Dehydrogenase from bovine liver
description ammonium sulfate suspension, 2,000-6,000 units/mg protein (biuret)	description lyophilized powder, ≥1500 units/mg protein	description BioUltra, lyophilized powder, ≥4,500 units/mg protein, ≥97% (SDS-PAGE)	description Type I, ammonium sulfate suspension, ≥40 units/mg protein
specific activity 2,000-6,000 units/mg protein (biuret)	specific activity ≥1500 units/mg protein	specific activity ≥4,500 units/mg protein	specific activity ≥40 units/mg protein
Gene Information cow ... SOD1(281495)	Gene Information cow ... SOD1(281495)	Gene Information -	Gene Information cow ... GLUD1(281785)
form ammonium sulfate suspension	form lyophilized powder	form lyophilized powder	form ammonium sulfate suspension
mol wt 32.5 kDa	mol wt 32.5 kDa	mol wt 32.5 kDa	mol wt 310-350 kDa
storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C
UniProt accession no. P00442	UniProt accession no. P00442	UniProt accession no. -	UniProt accession no. P00366

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Pictogrammes

GHS08

Mot-clé

Danger

Codes de danger

H334

Mentions de précaution

P261 - P284 - P501

Hazard Classifications

Resp. Sens. 1

Classe de stockage

10 - Combustible liquids

Que se passe-t-il ?

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

EPI (équipement de protection individuelle)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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