S6317

L-Sulforaphane

≥95% (HPLC), oil

• Synonyme(s) : (R)-1-Isothiocyanato-4-(methylsulfinyl)butane, 4-Methylsulfinylbutyl isothiocyanate
• Formule empirique (notation de Hill) : C₆H₁₁NOS₂
• Numéro CAS: 142825-10-3
• Poids moléculaire : 177.29
• Numéro MDL: MFCD09039283
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724618
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥95% (HPLC)
• Forme: oil
• Activité optique: [α]/D -70 to -90°, c = 1.0 in chloroform-d
• Couleur: light yellow
• Solubilité: DMSO: >5 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: CS(=O)CCCCN=C=S
• InChI: 1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3/t10-/m1/s1
• Clé InChI: SUVMJBTUFCVSAD-SNVBAGLBSA-N

Description

Application

L-Sulforaphane was used to study Nrf2-mediated signaling in mouse primary preadipocytes⁶ and murine macrophage RAW 264.7 cell line.⁷

Actions biochimiques/physiologiques

L-Sulforaphane is a potent, selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.

Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables.^3,4 It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.^3,5

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves