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RAB0402

Sigma-Aldrich

Human Platelet Factor-4 / CXCL4 ELISA Kit

for serum, plasma, cell culture supernatant and urine

Synonyme(s) :

C-X-C motif chemokine 4, Oncostatin-A, PF-4, Platelet factor 4, PF4

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About This Item

Code UNSPSC :
41116158
Nomenclature NACRES :
NA.32

Espèces réactives

human

Conditionnement

kit of 96 wells (12 strips x 8 wells)

Technique(s)

ELISA: suitable
capture ELISA: suitable

Entrée

sample type serum
sample type plasma
sample type urine
sample type cell culture supernatant(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 20 pg/mL
standard curve range: 20.58-15000 pg/mL

Méthode de détection

colorimetric

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... PF4(5196)

Catégories apparentées

Description générale

The Human PF-4 (Platelet Factor-4) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human PF-4 in serum, plasma, cell culture supernatants and urine.

Immunogène

Recombinant Human PF4

Application

For research use only. Not for use in diagnostic procedures.
Human Platelet Factor-4 (PF4)/ CXCL4 (chemokine (C-X-C motif) ligand 4) ELISA Kit has been used to measure PF-4 / CXCL4 serum level in chronic myelomonocytic leukemia (CMML) patients.
Human Platelet Factor-4 / CXCL4 ELISA Kit has also been used in the measurement of platelet factor-4 in serum samples of prostate cancer and pseudoxanthoma elasticum patients.

Actions biochimiques/physiologiques

Platelet factor-4 (PF-4) or chemokine (C-X-C motif) ligand 4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. This protein associates with heparin and neutralizes it. It also neutralizes various other negatively charged proteoglycans. PF-4 / CXCL4 is implicated in cancer development. PF-4 regulates the activity of proangiogenic growth factors. PF-4 / CXCL4 function as a biomarker for systemic sclerosis and early tumor growth. PF-4 / CXCL4 is associated with various pathological conditions such as atherosclerosis, liver fibrosis and inflammation.

Autres remarques

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Composants de kit également disponibles séparément

Réf. du produit
Description
FDS
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)FDS
  • RABELADCELISA 1X Assay/Sample Diluent Buffer C (Item L)FDS
  • RABSTOP3ELISA Stop Solution (Item I)FDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)FDS
  • RABWASH420X Wash Buffer (Item B)FDS

Pictogrammes

Corrosion
GHS05

Mention d'avertissement

Warning

Mentions de danger

H290

Conseils de prudence

P234 - P390

Classification des risques

Met. Corr. 1

Code de la classe de stockage

8A - Combustible corrosive hazardous materials

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis.
van Bon L
The New England Journal of Medicine, 370(5), 433-443 (2014)
Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia.
Meldi K
The Journal of Clinical Investigation, 125(5), 1857-1872 (2015)
Platelet-associated PF-4 as a biomarker of early tumor growth.
Cervi D
Blood, 111(3), 1201-1207 (2008)
L Joseph et al.
Journal of thrombosis and haemostasis : JTH, 12(7), 1044-1053 (2014-04-29)
Heparin-induced thrombocytopenia (HIT) is an adverse immune-mediated response to unfractionated heparin and, less commonly, low molecular weight heparin. It is associated with a high thrombotic risk and the potential for limb and life-threatening complications. Argatroban is the only approved and
CXCL4-platelet factor 4, heparin-induced thrombocytopenia and cancer.
Sandset PM
Thrombosis Research, 129 Suppl 1, S97-100 (2012)
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