As mentioned in the 'PROPERTIES' section, this product can be solubilized in chloroform at 50 mg/mL. In addition, this material is also soluble in DMSO at 5 mg/mL. DMSO stock solutions are stable for at least 6 months at -20°C. Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/140/282/r7772pis.pdf
R7772
Roscovitine
≥98% (TLC)
Synonyme(s) :
2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
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116,00 €
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424,00 €
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1 MG
116,00 €
5 MG
424,00 €
About This Item
Formule empirique (notation de Hill) :
C19H26N6O
Numéro CAS:
Poids moléculaire :
354.45
Numéro MDL:
Code UNSPSC :
12352200
ID de substance PubChem :
Nomenclature NACRES :
NA.77
Produits recommandés
Source biologique
synthetic (organic)
Essai
≥98% (TLC)
Forme
powder
Pf
106-107 °C
Solubilité
chloroform: 50 mg/mL, clear, colorless to light yellow
Température de stockage
−20°C
Chaîne SMILES
CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1
InChI
1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
Clé InChI
BTIHMVBBUGXLCJ-OAHLLOKOSA-N
Informations sur le gène
human ... CDK1(983) , CDK2(1017) , CDK5(1020) , CDK7(1022) , CDK9(1025) , CDKN1A(1026) , CDKN1B(1027) , CDKN1C(1028) , CDKN2A(1029) , CDKN2B(1030) , CDKN2C(1031) , CDKN2D(1032) , CDKN3(1033)
mouse ... CDK1(12534)
rat ... CDK1(54237)
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Application
Roscovitine has been used:
- an inhibitor of p34cdc2/cyclin B kinase to preculture porcine oocytes[1]
- as a supplement in TCM199 medium for in vitro prematuration of cumulus-oocyte complexes (COCs) of adult goats[2]
- in astrocyte conditioned media as an inhibitor of cyclin-dependent kinase 5 (CDK5)[3]
- as a CDK2 inhibitor in culture media to treat hESCs[4]
Actions biochimiques/physiologiques
Roscovitine is a potent, selective inhibitor of cyclin-dependent kinases.
Caractéristiques et avantages
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Informations légales
Sold under license from CNRS
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Les clients ont également consulté
Qian Liang et al.
Scientific reports, 3, 2932-2932 (2013-10-15)
Epithelial-mesenchymal transition is a change of cellular plasticity critical for embryonic development and tumor metastasis. CDK5 is a proline-directed serine/threonine kinase playing important roles in cancer progression. Here we show that CDK5 is commonly overexpressed and significantly correlated with several
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Cell reports, 4(3), 437-444 (2013-08-13)
The transcription factor STAT1 is important in natural killer (NK) cells, which provide immediate defense against tumor and virally infected cells. We show that mutation of a single phosphorylation site (Stat1-S727A) enhances NK cell cytotoxicity against a range of tumor
Bich Na Shin et al.
Scientific reports, 9(1), 13032-13032 (2019-09-12)
Abnormal activation of cyclin-dependent kinase 5 (Cdk5) is associated with pathophysiological conditions. Ischemic preconditioning (IPC) can provide neuroprotective effects against subsequent lethal ischemic insult. The objective of this study was to determine how Cdk5 and related molecules could affect neuroprotection
Birth of piglets after transferring of in vitro-produced embryos pre-matured with R-roscovitine
Coy P, et al.
Reproduction (Cambridge, England), 129(6), 747-755 (2005)
Advances in Putrescine Research and Application, 4-4 (2013)
Articles
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
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In what solvent and at what concentration do I reconstitute Roscovitine (R7772) ?
1 réponse-
Utile ?
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