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R6527

Sigma-Aldrich

Reboxetine mesylate hydrate

>96% (HPLC), solid

Synonyme(s) :

(2R)-rel-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine, Edronax, Vestra

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About This Item

Formule empirique (notation de Hill):
C19H23NO3 · CH3SO3H · xH2O
Numéro CAS:
98769-84-7
Poids moléculaire :
409.50 (anhydrous basis)
Numéro MDL:
MFCD11046031
Code UNSPSC :
12352200
ID de substance PubChem :
24724592
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

>96% (HPLC)

Forme

solid

Conditions de stockage

desiccated

Couleur

white to tan

Solubilité

H2O: >5 mg/mL at ≤60 °C

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Chaîne SMILES 

O.CS(O)(=O)=O.CCOc1ccccc1O[C@@H]([C@H]2CNCCO2)c3ccccc3

InChI

1S/C19H23NO3.CH4O3S.H2O/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4;/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4);1H2/t18-,19-;;/m1../s1

Clé InChI

SZPHEVAYLIVGRC-BAMQSBMESA-N

Application

Reboxetine mesylate hydrate has been used as a selective norepinephrine transport blocker:
  • to study its effects on the surge of dopamine in the cortex of mice brain
  • to study its anti-immobility effects on the behavior of mice
  • to analyze its effects on the probabilistic reversal learning task in rodents

Actions biochimiques/physiologiques

Reboxetine exhibits anti-depressant activity.
Selektiver Noradrenalin-Aufnahme-Inhibitor

Caractéristiques et avantages

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

S Kasper et al.
Expert opinion on pharmacotherapy, 1(4), 771-782 (2001-03-16)
Several treatment approaches are available for treatment of depression. However, reboxetine is the first selective noradrenaline re-uptake inhibitor. Whereas formerly only noradrenaline re-uptake inhibitors with a mixed mechanism of action were available. These included action not only at noradrenergic, but
Patrick Neiens et al.
Biomedical chromatography : BMC, 32(7), e4231-e4231 (2018-03-04)
MS Binding Assays represent a label-free alternative to radioligand binding assays. In this study, we present an LC-ESI-MS/MS method for the quantification of (R,R)-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol [(R,R)-D-84, (R,R)-1], (S,S)-reboxetine [(S,S)-2], and (S)-citalopram [(S)-3] employed as highly selective nonlabeled reporter ligands in MS
Dennis K Miller et al.
The Journal of pharmacology and experimental therapeutics, 302(2), 687-695 (2002-07-20)
The present study determined whether repeated administration of the antidepressant and selective norepinephrine (NE) uptake inhibitor reboxetine resulted in an adaptive modification of the function of the NE transporters (NETs), serotonin (5-HT) transporters, or dopamine (DA) transporters. Because antidepressants may
Charlotte J W Connell et al.
Medicine and science in sports and exercise, 49(9), 1778-1788 (2017-04-30)
Fatigue-induced impairments in the control of eye movements are detectable via reduced eye movement velocity after a bout of prolonged, strenuous exercise. Slower eye movements caused by neural fatigue within the oculomotor system can be prevented by caffeine, and the
Jeremy Koppel et al.
Journal of neurochemistry, 148(1), 127-135 (2018-09-22)
In Alzheimer's disease, the phosphorylation of tau is a critical event preceding the formation of neurofibrillary tangles. Previous work exploring the impact of a dopamine blocking antipsychotic on tau phosphorylation in a tau transgenic model suggested that extracellular dopamine may
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