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R5143

Rutin hydrate

Name: Rutin hydrate
Brand: SIGMA

≥94% (HPLC), powder

Synonyme(s) :

Quercetin-3-rutinoside hydrate, Vitamin P hydrate

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About This Item

Formule empirique (notation de Hill) :

C₂₇H₃₀O₁₆ · xH₂O

Numéro CAS:

207671-50-9

Poids moléculaire :

610.52 (anhydrous basis)

Beilstein:

75455

Numéro CE :

205-814-1

Numéro MDL:

MFCD01319140

Code UNSPSC :

12352201

ID de substance PubChem :

24899379

Nomenclature NACRES :

NA.25

Le tarif et la disponibilité ne sont pas disponibles actuellement.

Essai

≥94% (HPLC)

Forme

powder

Couleur

yellow to green

Pf

195 °C (dec.) (lit.)

Solubilité

pyridine: 50 mg/mL
DMSO: soluble
aqueous base: soluble

Application(s)

metabolomics
vitamins, nutraceuticals, and natural products

Chaîne SMILES

[H]O[H].O[C@H]1[C@H](OC[C@H]([C@H]2O)O[C@@H](OC(C3=O)=C(C4=CC=C(O)C(O)=C4)OC5=C3C(O)=CC(O)=C5)[C@H](O)[C@H]2O)O[C@H]([C@@H]([C@H]1O)O)C

InChI

1S/C27H30O16.H2O/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9;/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3;1H2/t8-,15+,17-,18+,20+,21-,22+,23+,26+,27-;/m0./s1

Clé InChI

PGHSKTKIQIBATG-ZAAWVBGYSA-N

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Catégories apparentées

Biochemicals

Natural Products for Research and Discovery

Description générale

Rutin hydrate has radioprotective[1] and antiplatelet activity.[2] Rutin reduces hepatic and blood cholesterol levels.[2]

Application

Rutin hydrate has been used:

as an inhibitory compound against Skeletonema costatum[3]
to analyze the phenolic component and antioxidant activity of nettle[4]
to assess the flavonoid content in Propolis[5]

Actions biochimiques/physiologiques

A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B₁ and N-nitrosodiumethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase β and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number

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In-vitro evaluation of rutin and rutin hydrate as potential radiation countermeasure agents

Ojha H, et al.

International Journal of Radiation Research, 14(1), 9-9 (2016)

Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells.

E A Mazzio et al.

Planta medica, 64(7), 603-606 (1998-11-12)

Glial cell monoamine oxidase (MAO) activity has been implicated as a contributor to oxidative neuronal damage associated with various neurodegenerative diseases. The attenuation of MAO activity may provide protection against oxidative neurodegeneration. In this investigation, the presence of MAO-B in

Estimation of total flavonoid content in propolis by two complementary colorimetric methods

Chang CC, et al.

Journal of food and drug analysis, 10(3) (2002)

Flavonoids as scavengers of nitric oxide radical.

S A van Acker et al.

Biochemical and biophysical research communications, 214(3), 755-759 (1995-09-25)

Flavonoids are a group of naturally occurring compounds used, e.g., in the treatment of vascular endothelial damage. They are known to be excellent scavengers of oxygen free radicals. Since the nitric oxide radical (.NO) probably plays a role in this

Protective effect of rutin, a flavonol glycoside, on the carcinogen-induced DNA damage and repair enzymes in rats.

R P Webster et al.

Cancer letters, 109(1-2), 185-191 (1996-12-03)

Administration of hepatocarcinogens aflatoxin B1 and N-nitrosodimethylamine to rats caused single-strand breaks in nuclear DNA. Inclusion in the diet of rutin, a naturally occurring phenolic flavonoid glycoside, significantly reduced the appearance of such breaks. The protection against DNA damage was

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Protocoles

HPLC Analysis of Polyphenols in Nero d'Avola Red Wine on Discovery® HS C18 (UV 280 nm)

Questions

1–2 sur 2 questions

Anonyme

il y a 2 mois

How is shipping temperature determined? And how is it related to the product storage temperature?

1 réponse
1. Technical Support
  
  il y a 2 mois
  
  Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
  
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Anonyme

il y a 2 mois

How can I determine the shelf life / expiration / retest date of this product?

1 réponse
1. Technical Support
  
  il y a 2 mois
  
  If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
  For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
  For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
  For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf
  
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