P6374
p53 human
recombinant, expressed in baculovirus infected Sf21 cells
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About This Item
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.25
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Produits recommandés
Source biologique
human
Niveau de qualité
Produit recombinant
expressed in baculovirus infected Sf21 cells
Essai
≥90% (SDS-PAGE)
Forme
aqueous solution
Technique(s)
dot blot: suitable
Numéro d'accès UniProt
Application(s)
genomic analysis
Conditions d'expédition
dry ice
Température de stockage
−70°C
Informations sur le gène
human ... TP53(7157)
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Description générale
p53 protein is composed of an N-terminal domain with a transactivation domain and proline-rich region, a central core-DNA binding domain, and a C-terminal domain with tetramerization and regulatory domains.[1] The TP53 gene which encodes for the p53 protein is mapped on the human chromosome at 17p13.1.[2]
Application
Useful for the study of postranslational modification of p53, or protein-protein interaction studies.
p53 human has been used in dot blot.[3]
Actions biochimiques/physiologiques
In addition, p53 was recently shown to induce differentiation of human embryonic stem cells. The effect is dependent on the DNA binding activity of p53. [4]
p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.
p53 protein acts as a transcription factor that participates in regulating positively or negatively the expression of several responsive genes. It plays a role in regulating angiogenesis, cellular senescence, autophagy, cell survival, differentiation, and oxidative stress. Mutations in the TP53 gene lead to Li Fraumeni cancer syndrome.[5]
Propriétés physiques
Histidine-tagged, full length human p53
Forme physique
Supplied as a solution in 20 mM Tris-HCl, pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA, and 1 mM DTT.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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p53: structure, function and therapeutic applications
Bai L and Zhu W
Journal of Cancer Molecules, 2(4), 141-153 (2006)
Cristian A Lasagna-Reeves et al.
Biochemical and biophysical research communications, 430(3), 963-968 (2012-12-25)
The tumor suppressor p53 plays an important role in genome integrity. It is frequently mutated in all types of human cancers, making p53 a key factor in cancer progression. Two phenotypic consequences of these alterations are dominant; a loss of
Fiamma Mantovani et al.
Cell death and differentiation, 26(2), 199-212 (2018-12-13)
Forty years of research have established that the p53 tumor suppressor provides a major barrier to neoplastic transformation and tumor progression by its unique ability to act as an extremely sensitive collector of stress inputs, and to coordinate a complex
Adam Shlien et al.
American journal of human genetics, 87(5), 631-642 (2010-11-09)
DNA copy-number variations (CNVs) underlie many neuropsychiatric conditions, but they have been less studied in cancer. We report the association of a 17p13.1 CNV, childhood-onset developmental delay (DD), and cancer. Through a screen of over 4000 patients with diverse diagnoses
Se Kyung Lee et al.
PloS one, 10(8), e0124658-e0124658 (2015-08-05)
Overexpression of p53 is the most frequent genetic alteration in breast cancer. Recently, many studies have shown that the expression of mutant p53 differs for each subtype of breast cancer and is associated with different prognoses. In this study, we
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