P5864

Proteoglycan from bovine nasal septum

chromatographically purified

• Synonyme(s) : Bovine Proteoglycan, Nasal Proteoglycan
• Numéro MDL: MFCD00212609
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.61

Propriétés

• Source biologique: bovine nasal septum
• Niveau de qualité: 100
• Forme: powder
• Technique(s): cell culture | stem cell: suitable
• Numéro d'accès UniProt: F1MDS0
• Température de stockage: −20°C
• Informations sur le gène: bovine ... PRG4(280867)

Description

Description générale

Proteoglycans are made up of a core protein to which glycosaminoglycan chains are linked covalently. They are present in many organs, and tissues and found abundantly in the vertebrate cartilage matrix. Proteoglycans are located in the extracellular and pericellular matrix of many cells.

Application

Proteoglycan from bovine nasal septum contains 86% chondroitin sulfate and so has been used to study the effects of chondroitin sulfate proteoglycan in vitro. It has been shown to promote survival of neural stem cells in culture. [1]

Proteoglycan from bovine nasal septum has been used in the induction of arthritis in mice.

Actions biochimiques/physiologiques

Proteoglycans are involved in tissue organization and promote cell growth and specialized tissue maturation. They act as biological filters and regulate collagen fibrillogenesis, skin tensile strength, and neurite growth. Proteoglycans are also involved in modulating growth-factor activities, affecting tumor cell growth and invasion, and promoting corneal transparency.

Notes préparatoires

Chromatographically purified using 7M urea on DEAE-cellulose by modified procedure by Antonopoulos.[2]

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)