P5607

L-Proline

98.5-101.0% dry basis, suitable for cell culture, non-animal source, meets EP, USP testing specifications

• Synonyme(s) : Acide (S)-pyrrolidine-2-carboxylique
• Formule empirique (notation de Hill) : C₅H₉NO₂
• Numéro CAS: 147-85-3
• Poids moléculaire : 115.13
• Beilstein: 80810
• Numéro CE : 205-702-2
• Numéro MDL: MFCD00064318
• Code UNSPSC : 12352209
• eCl@ss : 32160406
• ID de substance PubChem : 24898677
• Nomenclature NACRES : NA.26

Propriétés

• Nom du produit: L-Proline, from non-animal source, meets EP, USP testing specifications, suitable for cell culture
• Source biologique: non-animal source
• Agence: meets EP testing specifications; meets USP testing specifications
• Essai: 98.5-101.0% dry basis
• Forme: powder
• Activité optique: [α]20/D -86.0 to -84.0 °, c = 4 in water; [α]25/D -86.3 to -84.3°, c = 4 in water
• Technique(s): cell culture | mammalian: suitable
• Impuretés: endotoxin, tested
• Couleur: white
• Pf: 228 °C (dec.) (lit.)
• Solubilité: H₂O: 50 mg/mL
• Traces de cations: Fe: ≤10 ppm; NH₄⁺: ≤0.02%
• Application(s): pharmaceutical (small molecule)
• Groupe fonctionnel: (Imine); carboxylic acid
• Température de stockage: room temp
• Chaîne SMILES: OC(=O)[C@@H]1CCCN1
• InChI: 1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1
• Clé InChI: ONIBWKKTOPOVIA-BYPYZUCNSA-N

Description

Description générale

L-Proline, also known as 2-Pyrrolidinecarboxylic acid, is a versatile amino acid that plays an essential role in various biological processes. It is classified as a member of the glutamine family of amino acids and serves as a building block for proteins. L-Proline is vital for maintaining the structural integrity of proteins, including collagen, which is crucial for the proper functioning of joints, tendons, and various connective tissues.

This amino acid, synthesized within the human body from other amino acids, is involved in a range of functions. It contributes to wound healing, supports the synthesis of essential molecules such as elastin and carnitine, and is a key player in protein synthesis and structural stability. L-Proline is also associated with metabolic processes, including the synthesis of arginine, polyamines, and glutamate. In the realm of nutrition, it is known for its antioxidative properties and its role in immune responses.

Additionally, It also influences carbohydrate metabolism, cell growth, proliferation, and the maintenance of normal bodily functions. In cellular studies, it has demonstrated its ability to stimulate the growth of specific cell types while inhibiting the growth of others, making it a multifaceted component of various biological systems.

Moreover, L-Proline operates as a signaling molecule, participating in redox reactions and serving as a sensor of cellular energy status. It is involved in differentiation processes, impacting embryonic stem cells and the growth and development of the conceptus (fetus and associated extraembryonic membranes) in humans and animals[1]. L-Proline is a critical amino acid that plays a diverse and significant role in various biochemical and cellular processes, making it a valuable subject of study in fields such as biochemistry, microbiology, metabolism, cell biology, and nutrition research.

Application

L-proline has been used as a component of high-glucose-Dulbecco′s modified Eagle′s medium (HG-DMEM) for chondrocyte differentiation[2] and for the culture of chondrocyte-like cells.[3] It has also been used as a component of yeast nitrogen base for yeast cultures.[4]

Actions biochimiques/physiologiques

Proline is a cyclic, non-essential, hydrophobic amino acid.[5] It is a proteinogenic amino acid which is crucial for primary metabolism.[6] In peptide chains, proline residues confer structural constraints and enhance the susceptibility of proximal peptide bonds to protease activity.[7]

Caractéristiques et avantages

• Can be used in Metabolomics and Biochemical research
• High-quality compound suitable for multiple research applications

Autres remarques

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)