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Principaux documents

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P4374

Sigma-Aldrich

Phthalocyanine tetrasulfonate hydrate

solid

Synonyme(s) :

29H,29H,31H-Phthalocyanine-C,C,C,C-tetrasulfonic acid, PcTS, Phthalocyanine tetrasulfonic acid, Tetrasulfophthalocyanine

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About This Item

Formule empirique (notation de Hill):
C32H18N8O12S4 · xH2O
Numéro CAS:
1173097-70-5
Poids moléculaire :
834.79 (anhydrous basis)
Numéro MDL:
MFCD08276972
Code UNSPSC :
12352200
ID de substance PubChem :
24724578

Forme

solid

Niveau de qualité

100

Conditions de stockage

protect from light

Couleur

dark blue

Température de stockage

2-8°C

Chaîne SMILES 

[H]O[H].OS(=O)(=O)c1ccc2c3nc(nc4[nH]c(nc5nc(nc6[nH]c(n3)c7cc(ccc67)S(O)(=O)=O)c8cc(ccc58)S(O)(=O)=O)c9cc(ccc49)S(O)(=O)=O)c2c1

InChI

1S/C32H18N8O12S4.H2O/c41-53(42,43)13-1-5-17-21(9-13)29-33-25(17)37-30-22-10-14(54(44,45)46)2-6-18(22)27(34-30)39-32-24-12-16(56(50,51)52)4-8-20(24)28(36-32)40-31-23-11-15(55(47,48)49)3-7-19(23)26(35-31)38-29;/h1-12H,(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H2,33,34,35,36,37,38,39,40);1H2

Clé InChI

QNPPZKALMXYKPI-UHFFFAOYSA-N

Application

Phthalocyanine tetrasulfonate hydrate has been used as a tau aggregation inhibitor (TAI) to study its effects on Tau secretion in neuroblastoma cells[1]. It has also been used as an anionic phthalocyanine to study its effects on telomere G-quadruplex stabilization.[2]

Actions biochimiques/physiologiques

Inhibitor of protein aggregation, including α-synuclein, and the formation of protease-resistant prion protein.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
080M4719
125K4710

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Iron(II) phthalocyanine Dye content ~90 %

Sigma-Aldrich

379549

Iron(II) phthalocyanine

Zinc phthalocyanine Dye content 97 %

Sigma-Aldrich

341169

Zinc phthalocyanine

Chang-yue Chen et al.
Journal of the American Chemical Society, 133(38), 15036-15044 (2011-08-19)
Inhibition of telomerase activity through stabilizing telomere G-quadruplex with small chemical ligands is emerging as a novel strategy for cancer therapy. For the large number of ligands that have been reported to inhibit telomerase activity, it is difficult to validate
Maria Merezhko et al.
Cell reports, 25(8), 2027-2035 (2018-11-22)
Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that appear to spread throughout the brain via a cell-to-cell transmission process that includes secretion and uptake of pathological Tau, followed by templated misfolding of normal Tau in recipient cells.
Takao Ohtomo et al.
Journal of analytical methods in chemistry, 2012, 520248-520248 (2012-05-09)
The chemiluminescence (CL) signal immediately appeared when a hydrogen peroxide solution was injected into an iron-phthalocyanine tetrasulfonic acid (Fe-PTS) aqueous solution. Moreover, the CL intensity of Fe-PTS decreased by adding l-tyrosine. Based on these results, the determination of trace amounts
Ciaran K McLoughlin et al.
Sensors (Basel, Switzerland), 20(18) (2020-09-16)
Fluorescein, and derivatives of fluorescein, are often used as fluorescent probes and sensors. In systems where pH is a variable, protonation/deprotonation of the molecule can influence the pertinent photophysics. Fluorination of the xanthene moiety can alter the molecule's pKa such
Luis Fonseca-Ornelas et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 23(53), 13010-13014 (2017-08-02)
Accumulation of α-synuclein (αSyn) aggregates constitutes the hallmark of synucleinopathies including Parkinson's disease. However, many steps from the innocuous, monomeric αSyn toward misfolded oligomers and fibrillar species remain unclear. Here, we show that αSyn can form in solution α-helical oligomers
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