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P1941

Sigma-Aldrich

Poly(D,L-lactide-co-glycolide)

lactide:glycolide (75:25), mol wt 66,000-107,000

Synonyme(s) :

LACTEL® B6007-1, PLGA

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1 G
106,00 €
5 G
405,00 €

About This Item

Formule linéaire :
[C3H4O2]x[C2H2O2]y
Numéro MDL:
MFCD00131930
Code UNSPSC :
12162002
ID de substance PubChem :
24898256
Nomenclature NACRES :
NA.26

106,00 €

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Devis pour commande en gros

Forme

pellets

Ratio alimentaire

lactide:glycolide (75:25)

Poids mol.

66,000-107,000

Température de stockage

−20°C

Chaîne SMILES 

OCC(O)=O.CC(O)C(O)=O

Clé InChI

XBBVURRQGJPTHH-UHFFFAOYSA-N

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Description générale

The product is an amorphous solid with a transition temperature (Tg) in the range of 45-50°C. It is soluble in most organic solvents such as methylene chloride, tetrahydrofuran, ethyl acetate, acetone, chloroform, and hexafluoroispropanol.

Application

Poly(D,L-lactide-co-glycolide) is a synthetic amino acid that has been used to deliver macromolecular therapeutics.[1]

Caractéristiques et avantages

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

Forme physique

Biocompatible, biodegradable polymer.

Informations légales

Lactel is a registered trademark of Evonik Corp

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
MKCX1543
MKCX2379
MKCW3547
MKCT4293
0000238445

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

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Fabrication of amorphous strontium polyphosphate microparticles that induce mineralization of bone cells in vitro and in vivo
Werner E.G.Muller
Acta Biomaterialia, 50, 89-101 (2017)
Robert M Stefani et al.
Acta biomaterialia, 102, 326-340 (2019-12-06)
Articular cartilage defects are a common source of joint pain and dysfunction. We hypothesized that sustained low-dose dexamethasone (DEX) delivery via an acellular osteochondral implant would have a dual pro-anabolic and anti-catabolic effect, both supporting the functional integrity of adjacent
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Vanna Sanna et al.
International journal of nanomedicine, 7, 5501-5516 (2012-10-25)
Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or
Afficher tous les articles scientifiques apparentés

Articles

Biodegradable Aliphatic Polyesters for Drug Delivery

Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Questions

1–3 sur 3 questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 réponse

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 réponse

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What is solubility information of plga 75:25

    1 réponse

    1. The solubility of this product is not determined. However, various sources state that Poly(D, L-lactide-co-glycolide) is soluble in organic solvents such as methylene chloride, tetrahydrofuran, ethyl acetate, acetone, chloroform, and hexafluoroisopropanol. The concentration has not been determined for these solvents.

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