The product specification does not include a base pair length, and it is not determined in quality control testing. The best estimate is that the polymer is a mixture of different lengths ranging from 150 base pairs to 2,000 base pairs. Users requiring more specificity of the base pair lengths may need to determine it using gel electrophoresis.
P1537
Polyadenylic acid-Polyuridylic acid sodium salt
double-stranded homopolymer
Synonyme(s) :
Poly[A]•Poly[U]
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10 MG
346,00 €
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10 MG
346,00 €
About This Item
Produits recommandés
Niveau de qualité
Forme
powder
Température de stockage
−20°C
Chaîne SMILES
[P](=O)(OC[C@H]3O[C@H]([C@@H]([C@@H]3O)O)[n]4c5ncnc(c5nc4)N)(O)O.[P](=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)N2C=CC(=O)NC2=O)(O)O
InChI
1S/C10H14N5O7P.C9H13N2O9P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1
Clé InChI
VGQHQOKIMNKUEF-ZLOOHWKQSA-N
Application
Polyadenylic acid-Polyuridylic acid (polyAU) is a double stranded homodimer studied for potential therapeutic activity, especially when coupled with radiotherapy. PolyA/U is used in comparative physiochemical studies with other duplex and single-stranded polymers such as poly-A and poly-U.
Autres remarques
Double stranded homopolymer
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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Les clients ont également consulté
A Laplanche et al.
Breast cancer research and treatment, 64(2), 189-191 (2001-02-24)
With a median follow-up of 14 years, the combination of polyadenylic-polyuridylic acid plus locoregional radiotherapy (257 patients) has significantly improved disease-free survival (p = 0.03) and significantly reduced the incidence of metastases (p = 0.04) when compared to CMF alone
Polyadenylic acid-polyuridylic acid (poly A : U) and experimental murine brucellosis. II. Macrophages as target cells of poly A : U in experimental brucellosis.
E D Madraso et al.
Immunology, 35(1), 77-84 (1978-07-01)
Nathan W Luedtke et al.
Biochemistry, 42(39), 11391-11403 (2003-10-01)
Semisynthetic aminoglycoside derivatives may provide a means to selectively target viral RNA sites, including the HIV-1 Rev response element (RRE). The design, synthesis, and evaluation of derivatives based upon neomycin B, kanamycin A, and tobramycin conjugates of 9-aminoacridine are presented.
A A Ghazaryan et al.
Journal of biomolecular structure & dynamics, 24(1), 67-74 (2006-06-20)
We employed UV light absorption and circular dichroism (CD) spectroscopic measurements to study the binding of novel water-soluble porphyrins meso-tetra-(4N-allylpyridyl)porphyrin [TAlPyP4], and its Ag containing derivative to the poly(rA)poly(rU) and poly(rI)poly(rC) RNA duplexes. Our results suggest that TAlPyP4 associate with
Gerardo Gatti et al.
European journal of immunology, 43(7), 1849-1861 (2013-05-03)
Viral double-stranded RNA (dsRNA) mimetics have been explored in cancer immunotherapy to promote antitumoral immune response. Polyinosine-polycytidylic acid (poly I:C) and polyadenylic-polyuridylic acid (poly A:U) are synthetic analogs of viral dsRNA and strong inducers of type I interferon (IFN). We
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What is the average base pair length for this product
1 réponse-
Utile ?
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I'd like to know the homogeneity of this product, or at least the % A:U base pairing. My application is sensitive to high mismatch and single strand RNA content and I'm hoping this is at least 85% A:U base paired.
1 réponse-
Unfortunately, the homogeneity and A:U ratio are not determined for this product. The material is prepared by separately preparing polyA and polyU strands by an enzymatic method. The individual polyA and polyU strands are purified to remove low molecular weight species then annealed by heating, followed by a slow cooling process. Historical information indicates an approximate starting ratio of 1:2 molar concentration of Poly(A) to Poly(U), respectively. There is an estimated sodium content of 5 - 6%.
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