O4139

Orlistat

≥98% (HPLC), solid, lipase inhibitor

• Synonyme(s) : (−)-Tetrahydrolipstatin, N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, Ro-18-0647
• Formule empirique (notation de Hill): C₂₉H₅₃NO₅
• Numéro CAS: 96829-58-2
• Poids moléculaire : 495.73
• Numéro MDL: MFCD05662360
• Code UNSPSC : 41106300
• ID de substance PubChem : 24724564
• Nomenclature NACRES : NA.77

Propriétés

• product name: Orlistat, ≥98%, solid
• Source biologique: synthetic (organic)
• Pureté: ≥98%
• Forme: solid
• Couleur: white
• Pf: <50 °C
• Solubilité: DMSO: 19 mg/mL
• Auteur: Roche
• Température de stockage: 2-8°C
• Chaîne SMILES: CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
• InChI: 1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
• Clé InChI: AHLBNYSZXLDEJQ-FWEHEUNISA-N
• Informations sur le gène: human ... LIPF(8513) , PNLIP(5406)

Description

Description générale

Orlistat acts as a gastric lipase inhibitor that reduces fat absorption.

Application

Orlistat has been used as an inhibitor:

• of fatty acid synthase in long-term estrogen-deprived (LTED) variant cell lines
• of lipase in screening lipase inhibition by raspberry extract
• in in vitro pancreatic lipase activity assay

Actions biochimiques/physiologiques

Orlistat impairs intestinal fat absorption and is effective in weight management. It is regarded as a safe drug for treating obesity. It delays the progression of type 2 diabetes mellitus especially in obese and improves glycemic parameters. Long term usage of orlistat results in improved weight reduction and it may not contribute in colorectal carcinogenesis.

Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase.

Caractéristiques et avantages

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Autres remarques

Solution is not completely clear, small particles may remain floating.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)