O2756

Oxytetracycline hemicalcium salt

• Formule linéaire : C₂₂H₂₄N₂O₉ · 1/2Ca
• Numéro CAS: 15251-48-6
• Poids moléculaire : 480.47
• Numéro CE : 239-293-7
• Numéro MDL: MFCD00151362
• Code UNSPSC : 51101500
• ID de substance PubChem : 24897968

Propriétés

• Solubilité: formic acid: 50 mg/mL, very slightly hazy, orange to very deep orange
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria
• Mode d’action: protein synthesis | interferes
• Température de stockage: 2-8°C
• Chaîne SMILES: [Ca++].CN(C)[C@H]1[C@@H]2[C@@H](O)C3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1[O-])C(=O)c4c(O)cccc4[C@@]3(C)O.CN(C)[C@H]5[C@@H]6[C@@H](O)C7C(=C(O)[C@]6(O)C(=O)C(C(N)=O)=C5[O-])C(=O)c8c(O)cccc8[C@@]7(C)O
• InChI: 1S/2C22H24N2O9.Ca/c2*1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h2*4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);/q;;+2/p-2/t2*12?,13-,14+,17+,21-,22+;/m11./s1
• Clé InChI: KIPLYOUQVMMOHB-JOFVZRTQSA-L

Description

Description générale

Chemical structure: tetracycline

Application

Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. Oxytetracycline is an antibiotic indicated for treatment of infections caused by Gram positive and Gram negative microorganisms such as Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae, and Diplococcus pneumoniae. It is used in studies on the oxytetracycline-resistance gene (otrA). It is used for fluorescence measurements of hepatocytes.

Actions biochimiques/physiologiques

Oxytetracycline inhibits translation which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H361d,H411
• Conseils de prudence: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Classification des risques: Aquatic Chronic 2 - Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)