N6909

Neurturin human

>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

• Synonyme(s) : NRTN, NTN
• Numéro MDL: MFCD01867712
• Code UNSPSC : 51111800

Propriétés

• Source biologique: human
• Produit recombinant: expressed in E. coli
• Essai: >95% (SDS-PAGE)
• Forme: lyophilized powder
• Puissance: 15-50 ng/mL ED₅₀
• Poids mol.: monomer calculated mol wt ~12.5 kDa; predicted mol wt ~14 kDa by SDS-PAGE (reducing)
• Conditions de stockage: avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
• Impuretés: endotoxin, tested
• Numéro d'accès UniProt: Q99748
• Température de stockage: −20°C
• Informations sur le gène: human ... NRTN(4902)

Description

Actions biochimiques/physiologiques

Member of the glial cell line-derived neurotrophic factor family of ligands. Exerts potent effects on the function and survival of central and peripheral neurons. Activates the RET receptor tyrosine kinase, MAP kinase, and phosphatidylinositol 3-kinase pathways.

Member of the glial cell line-derived neurotrophic factor family of ligands. Exerts potent effects on the function and survival of central and peripheral neurons. Activates the RET receptor tyrosine kinase, MAP kinase, and phosphatidylinositol 3-kinase pathways. Human and mouse NTN share 91% sequence identity.

Forme physique

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.

Remarque sur l'analyse

The biological activity is measured by its ability to bind recombinant human GFRα2/Fc.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)