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N3663

Sigma-Aldrich

Anti-NeuroD1 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-BHF-1, Anti-NDF1, Anti-Neurogenic differentiation factor1

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About This Item

Numéro MDL:
MFCD03097085
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~45 kDa (doublet bands)

Espèces réactives

human, rat, mouse

Conditionnement

antibody small pack of 25 μL

Concentration

~1 mg/mL

Technique(s)

western blot: 0.5-1 μg/mL using whole extracts of HEK-293T cells expressing human NeuroD1

Numéro d'accès UniProt

Q13562

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... NEUROD1(4760)
mouse ... Neurod1(18012)
rat ... Neurod1(29458)

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Description générale

NeuroD1 gene is mapped to human chromosome 2q31.3.
Neuronal differentiation 1 (NEUROD1) is a transcription factor which is highly expressed in the brain, pancreas and retina.

Spécificité

Anti-NeuroD1 specifically recognizes human, mouse and rat NeuroD1.

Immunogène

synthetic peptide corresponding to amino acids 76-91 of human NeuroD1 conjugated to BSA. The corresponding sequence differs in mouse and rat by two and three amino acids, respectively.

Application

Anti-NeuroD1 antibody produced in rabbit has been used in chromatin immunoprecipitation and immunoblotting.

Actions biochimiques/physiologiques

NeuroD1 is a basic helix-loop-helix (bHLH) transcription factor, which regulates the fate of specific neuronal, endocrine and retinal cells.
Neuronal differentiation 1 (NEUROD1) binds to promoters and regulates gene expression. It can also enhance tumor cell survival in lung tumors. Mutations in the gene encoding NEUROD1 have been associated with neurological problems and early-onset diabetes.

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Stockage et stabilité

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificats d'analyse (COA)

Lot/Batch Number
048K4800

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Lack of association between NeuroD1/D6 gene polymorphism and heroin dependence in Han-chinese male population
Tsou CC, et al.
Journal of Medical Sciences, 38(5), 228-228 (2018)
Feng Wang et al.
Investigative ophthalmology & visual science, 56(1), 150-155 (2014-12-06)
Mutations in the same gene can lead to different clinical phenotypes. In this study, we aim to identify novel genotype-phenotype correlations and novel disease genes by analyzing an unsolved autosomal recessive retinitis pigmentosa (ARRP) Han Chinese family. Whole exome sequencing
Winifred P S Wong et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(29), 13057-13062 (2010-07-10)
Estrogen receptors (ERs) protect pancreatic islet survival in mice through rapid extranuclear actions. ERalpha also enhances insulin synthesis in cultured islets. Whether ERalpha stimulates insulin synthesis in vivo and, if so, through which mechanism(s) remain largely unknown. To address these
Jihan K Osborne et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6524-6529 (2013-04-05)
Small-cell lung cancer and other aggressive neuroendocrine cancers are often associated with early dissemination and frequent metastases. We demonstrate that neurogenic differentiation 1 (NeuroD1) is a regulatory hub securing cross talk among survival and migratory-inducing signaling pathways in neuroendocrine lung

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