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N179

Sigma-Aldrich

NS 102

solid

Synonyme(s) :

6,7,8,9-Tetrahydro-5-nitro-1H-benz[g]indole-2,3-dione 3-oxime

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About This Item

Formule empirique (notation de Hill):
C12H11N3O4
Numéro CAS:
136623-01-3
Poids moléculaire :
261.23
Code UNSPSC :
12352200
ID de substance PubChem :
24897529
Nomenclature NACRES :
NA.32

Forme

solid

Couleur

yellow

Solubilité

DMSO: >3 mg/mL
H2O: insoluble
methanol: insoluble

Chaîne SMILES 

O\N=C1/C(=O)Nc2c3CCCCc3c(cc12)[N+]([O-])=O

InChI

1S/C12H11N3O4/c16-12-11(14-17)8-5-9(15(18)19)6-3-1-2-4-7(6)10(8)13-12/h5,17H,1-4H2,(H,13,14,16)

Clé InChI

SCDBMLHUXJBJSS-UHFFFAOYSA-N

Informations sur le gène

human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRIN3A(116443) , GRIN3B(116444) , GRINA(2907)
mouse ... GRIN1(14810) , GRIN2A(14811) , GRIN2B(14812) , GRIN2C(14813) , GRIN2D(14814) , GRIN3A(242443) , GRIN3B(170483) , GRINA(66168)
rat ... GRIN1(24408) , GRIN2A(24409) , GRIN2B(24410) , GRIN2C(24411) , GRIN2D(24412) , GRIN3A(191573) , GRIN3B(170796) , GRINA(266668)

Actions biochimiques/physiologiques

Competitive glutamate receptor antagonist with high selectivity for the low-affinity [3H] kainate binding site.

Informations légales

Sold under exclusive license from NeuroSearch A/S.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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R A Tasker et al.
Canadian journal of physiology and pharmacology, 74(9), 1047-1054 (1996-09-01)
Our objective was to characterize the neurotoxic actions of systemically administered domoic acid on different excitatory amino acid receptors, and to compare the receptor selectivity of domoate with the related compound kainic acid. Groups of mice were injected with various
T H Johansen et al.
European journal of pharmacology, 246(3), 195-204 (1993-08-15)
5-Nitro-6,7,8,9-tetrahydrobenzo[G]indole-2,3-dione-3-oxime (NS-102), a new competitive glutamate receptor antagonist displaced binding to non-N-methyl-D-aspartate (non-NMDA) binding sites with no activity at the NMDA and strychnine-insensitive glycine binding sites. Under experimental conditions in which both high- and low-affinity sites were labelled, NS-102 only
H Kamiya et al.
The Journal of physiology, 509 ( Pt 3), 833-845 (1998-05-23)
1. The effect of a low concentration (1 microM) of kainate (kainic acid; KA) on presynaptic calcium (Ca2+) influx at the Schaffer collateral-commissural (SCC) synapse was examined in rat hippocampal slices. 2. Following selective loading of the presynaptic terminals with
Toshiaki Minami et al.
British journal of pharmacology, 142(4), 679-688 (2004-05-26)
1. Ingestion of a poisonous mushroom Clitocybe acromelalga is known to cause severe tactile pain (allodynia) in the extremities for a month and acromelic acid (ACRO), a kainate analogue isolated from the mushroom, produces selective damage of interneurons of the
Hubert Monnerie et al.
Journal of neuroscience research, 83(6), 944-956 (2006-02-25)
Glutamate is an important regulator of dendrite development that may inhibit, (during ischemic injury), or facilitate (during early development) dendrite growth. Previous studies have reported mainly on the N-methyl-D-aspartate (NMDA) receptor-mediated dendrite growth-promoting effect of glutamate. In this study, we
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