MAK422
ACE1 Inhibitor Screening Kit (Colorimetric)
sufficient for 100 colorimetric tests
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About This Item
Code UNSPSC :
12161503
Produits recommandés
Méthode de détection
colorimetric
Maladie(s) pertinente(s)
endocrinological disorders, diabetes; cardiovascular diseases; neurological disorders
Température de stockage
−20°C
Description générale
Angiotensin-I-converting enzyme (ACE) is a peptidyl dipeptidase that catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II, by removing a carboxy-terminal dipeptide. ACE is a key part of the renin angiotensin system that regulates blood pressure. ACE inhibitor inhibits ACE1 enzymatic activity and decreases the production of angiotensin II. As a result, blood vessels are dilated thereby increasing the amount of blood pumped by the heart and lowering the blood pressure. ACE inhibitors are used for treating hypertension, heart failure, stroke etc. Recent research is also focused on the discovery of natural products as ACE1 Inhibitors.
Caractéristiques et avantages
ACE1 Inhibitor Screening Kit:
- Compatible with high-throughput handling systems.
Adéquation
The kit is suitable for the screening/characterizing of ACE1 inhibitors.
Principe
The ACE1 Inhibitor Screening Kit can be used to screen potential ACE1 inhibitors. The kit utilizes the ability of an active ACE1 to hydrolyze a synthetic substrate, which results in the decrease in A345 nm. In the presence of Captopril, an ACE1 specific inhibitor, the ACE1 enzymatic activity is greatly reduced and there is no significant decrease in the A345 nm. The assay kit provides a rapid, simple and reliable test for high-throughput screening of ACE1 inhibitors.
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Repr. 1B
Code de la classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
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