MAK177
Ceruloplasmin Activity Colorimetric Kit
Sufficient for 100 Colorimetric tests
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.25
Produits recommandés
Description générale
Ceruloplasmin is a multifunctional copper-containing ferroxidase present in serum. Ceruolpasmin is the major transporter of copper in the blood, carrying more than 95% of the copper found in plasma. It uses copper to couple the oxidation of substrate with the reduction of oxygen to water. Ceruloplasmin-mediated oxidation of ferrous (Fe2+) iron to ferric (Fe3+) iron contributes to the regulation of iron efflux in cells that have transportable iron stores. Inherited loss-of-function mutations in ceruloplasmin has been linked to aceruloplasminemia. Ceruloplasmin is known to form complexes with cationic proteins during inflammation and is also involved in preventing iron-induced oxidative damage. Increased ceruloplasmin levels have been observed in celiac and Crohn′s patients. Elevated serum ceruloplasmin has also been linked to cancer, pregnancy, rheumatoid arthritis, schizophrenia, and Alzheimer′s disease, whereas its low levels have been linked to Wilson′s and Menkes′ diseases. Hence, measurement of ceruloplasmin activity in biological samples can provide useful insights into several metabolic and pathological conditions.
Application
Ceruloplasmin Activity Colorimetric Kit has been used to measure serum ceruloplasmin quantity and activity.
Adéquation
Suitable for the detection of ceruloplasmin activity in serum.
Principe
The Ceruloplasmin Activity Colorimetric Kit provides a fast and easy-to-use procedure for measuring ceruloplasmin activity in serum. Ceruloplasmin activity is determined using substrate oxidation, which results in a colorimetric (560 nm) product proportional to the enzymatic activity present. One unit of ceruloplasmin is the amount of enzyme that will oxidize 1 μmole of substrate per minute at 25 °C.
Composants de kit seuls
Réf. du produit
Description
- Ceruloplasmin Assay Buffer
- Ammonium Sulfate, saturated (∼4.1 M)
- Ceruloplasmin Substrate
- Oxidizer (100 mM)
- Stabilizer
Mentions de danger
Conseils de prudence
Classification des risques
Aquatic Chronic 3
Code de la classe de stockage
10 - Combustible liquids
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Nadia Abdel-Magied et al.
Biological trace element research, 194(2), 410-422 (2019-07-18)
Low-level laser therapy (LLLT) is a type of medicine that uses laser light at low levels to activate the cellular chromophores and the initiation of cellular signaling. This study aimed to evaluate the photomodulation effect of LLL against ionizing radiation
Tai-Di Chen et al.
Genetics, 206(2), 1139-1151 (2017-04-30)
Crescentic glomerulonephritis (Crgn) is a complex disorder where macrophage activity and infiltration are significant effector causes. In previous linkage studies using the uniquely susceptible Wistar Kyoto (WKY) rat strain, we have identified multiple crescentic glomerulonephritis QTL (Crgn) and positionally cloned
Varadarajan Sudhahar et al.
Arteriosclerosis, thrombosis, and vascular biology, 39(11), 2320-2337 (2019-09-27)
Copper (Cu) is essential micronutrient, and its dysregulation is implicated in aortic aneurysm (AA) development. The Cu exporter ATP7A (copper-transporting P-type ATPase/Menkes ATPase) delivers Cu via the Cu chaperone Atox1 (antioxidant 1) to secretory Cu enzymes, such as lysyl oxidase
Jereme G Spiers et al.
Antioxidants (Basel, Switzerland), 11(1) (2022-01-22)
Essential metals such as copper, iron, and zinc are cofactors in various biological processes including oxygen utilisation, cell growth, and biomolecular synthesis. The homeostasis of these essential metals is carefully controlled through a system of protein transporters involved in the
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique