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M9269

Sigma-Aldrich

IgG1, Kappa from murine myeloma

clone MOPC 21, purified immunoglobulin, buffered aqueous solution

Synonyme(s) :

Mouse IgG1-κ

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About This Item

Numéro MDL:
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Clone

MOPC 21, monoclonal

Forme

buffered aqueous solution

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

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Spécificité

Specificity is determined by mouse monoclonal isotyping strips. The purified immunoglobulin preparation is non-reactive with anti mouse IgA, IgM, IgG2a, IgG2b or IgG3

Application

IgG1, κ from murine myeloma has been used in:
  • the in situ hybridization experiments with bulbar conjunctiva sections
  • immunohistochemistry of cattle and artery tissues
IgG1, κ from murine myeloma has been used:
  • in immunofluorescence of leukocytes at a concentration of 50 μg/ml
  • as a standard in enzyme linked immunosorbent assay (ELISA)
  • as exchange antibody in centrifugal gel filtration
IgG1, Kappa from murine myeloma has been used in flow cytometric analysis and immunoprecipitation.

Actions biochimiques/physiologiques

IgG antibody subtype is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.
IgG1 has a molecular weight of 146 kDa and is an abundantly expressed IgG subclass. IgG1 deficiencies contribute to overall decrease in total IgG levels resulting in hypogammaglobulinemia. IgG1 promotes bacterial phagocytosis and mediates vaccine-induced protection from infection. The ratio of IgG2a to IgG1 is crucial for the immune response against Leishmania tropica infection. It has high binding affinity towards the Fcγ receptors (FcγR). High levels of IgG1-κ antibodies is associated with the pathology of glomerulonephritis.

Forme physique

Solution in 0.02 M Tris buffered saline, pH 8.0, containing 0.02% sodium azide

Stockage et stabilité

Store at −20 °C. The product may be stored frozen in working aliquots at −20 °C. Repeated freezing and thawing is not recommended.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

The relative contribution of mast cell subsets to conjunctival TH2-like cytokines.
Anderson DF, et al.
Investigative Ophthalmology & Visual Science, 42(5), 995-1001 (2001)
Visceral tissue growth and proliferation during the bovine lactation cycle.
Baldwin RL, et al.
Journal of Dairy Science, 87(9), 2977-2986 (2004)
M Dellian et al.
British journal of cancer, 82(9), 1513-1518 (2000-05-02)
Molecular charge is one of the main determinants of transvascular transport. There are, however, no data available on the effect of molecular charge on microvascular permeability of macromolecules in solid tumours. To this end, we measured tumour microvascular permeability to
Circulating monoclonal IgG1-kappa antibodies causing anti-glomerular basement membrane nephritis.
Vankalakunti M, et al.
Indian journal of nephrology, 27(4), 327-327 (2017)
Cecilia Lässer et al.
Journal of visualized experiments : JoVE, (59), e3037-e3037 (2012-01-20)
The field of exosome research is rapidly expanding, with a dramatic increase in publications in recent years. These small vesicles (30-100 nm) of endocytic origin were first proposed to function as a way for reticulocytes to eradicate the transferrin receptor

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