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M8750

Sigma-Aldrich

(+)-Methamphetamine hydrochloride

Synonyme(s) :

d-Desoxyephedrine hydrochloride, d-N,α-Dimethylphenethylamine hydrochloride, Methylamphetamine hydrochloride

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About This Item

Formule empirique (notation de Hill):
C10H15N · HCl
Numéro CAS:
51-57-0
Poids moléculaire :
185.69
Numéro CE :
200-106-9
Numéro MDL:
MFCD00056130
Code UNSPSC :
12352116
ID de substance PubChem :
24897282
Nomenclature NACRES :
NA.77

Contrôle du médicament

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Solubilité

H2O: soluble
ethanol: soluble

Application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Auteur

Teva

Chaîne SMILES 

Cl[H].CN[C@@H](C)Cc1ccccc1

InChI

1S/C10H15N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h3-7,9,11H,8H2,1-2H3;1H/t9-;/m0./s1

Clé InChI

TWXDDNPPQUTEOV-FVGYRXGTSA-N

Informations sur le gène

human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

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Catégories apparentées

Actions biochimiques/physiologiques

Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.

Caractéristiques et avantages

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Autres remarques

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H300,H336

Conseils de prudence

P301 + P310 + P330

Classification des risques

Acute Tox. 2 Oral - STOT SE 3

Organes cibles

Central nervous system

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Kaveh Shahveisi et al.
Pharmacology, biochemistry, and behavior, 185, 172759-172759 (2019-08-16)
Susceptibility to interference can be a result of memory retrieval and reconsolidation. Given the fact that addiction develops through the neural mechanisms of learning and memory, it would not be surprising that a consolidated drug reward memory may also be
Noémie Cresto et al.
International journal of molecular sciences, 22(13) (2021-07-03)
Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson's disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understood. We previously showed that the
Xiaohui Wang et al.
ACS chemical neuroscience, 10(8), 3622-3634 (2019-07-10)
Methamphetamine (METH) is a globally abused, highly addictive stimulant. While investigations of the rewarding and motivational effects of METH have focused on neuronal actions, increasing evidence suggests that METH can also target microglia, the innate immune cells of the central
G J Rivière et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1220-1226 (1999-11-24)
The purpose of these studies was to better understand the behavioral effects and pharmacokinetics of an i.v. bolus dose of (+)-methamphetamine [(+)-METH] in a rat model of (+)-METH abuse. We characterized the behavioral effects after increasing (+)-METH doses (0.1, 0.3
Leila Rezaeian et al.
Iranian journal of basic medical sciences, 23(11), 1480-1488 (2020-11-26)
This research aimed at evaluating the effect of berberine hydrochloride on anxiety-related behaviors induced by methamphetamine (METH) in rats, assessing relapse and neuroprotective effects. 27 male Wistar rats were randomly assigned into groups of Control, METH-withdrawal (METH addiction and subsequent
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