M8523
Anti-β2-Microglobulin antibody produced in rabbit
whole antiserum
Synonyme(s) :
Anti-B2MG
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About This Item
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
whole antiserum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Contient
15 mM sodium azide
Espèces réactives
human
Conditionnement
antibody small pack of 25 μL
Technique(s)
indirect ELISA: 1:5,000
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... B2M(567)
Description générale
β-2-microglobulin is part of the human leukocyte antigen, where it represents the light chain. It is expressed on cell membranes and is made up of 99 amino acids. β-2-microglobulin is part of the immunoglobulin superfamily.
β2-microglobulin (B2M) is a non-glycosylated polypeptide. The protein is characterized with a single polypeptide chain, which is linked noncovalently to major histocompatibility complex (MHC) class I cell surface antigen. The gene coding for B2M is mapped to human chromosome 15q.
Immunogène
β2-microglobulin
Application
Anti-β2-Microglobulin antibody produced in rabbit has been used in immunoblottingand immunofluorescence.
Actions biochimiques/physiologiques
β-2-microglobulin acts as a tumor marker and has been shown to be associated with dialysis-related amyloidosis.
β2-microglobulin (B2M) plays a vital role in cell survival, proliferation and metastasis in various types of cancer. Elevated concentration of β-2-microglobulin (B2M) can be considered as a prognostic marker for hemophagocytic lymphohistiocytosis (HLH). Overexpression of serum B2M is observed in hepatitis C virus (HCV) related chronic liver diseases, therefore it might act as a potential marker for the HCV disease progression towards cirrhosis and carcinoma. Missense mutation in the B2M gene results in familial hypercatabolic hypoproteinemia (FHH).
Qualité
The antiserum has been treated to remove lipoprotens.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 3
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Certificats d'analyse (COA)
Lot/Batch Number
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Expression of the neonatal Fc-receptor in placental-fetal endothelium and in cells of the placental immune system
Kiskova T, et al.
Placenta, 78, 36-43 (2019)
Aruna P Ambagala et al.
Archives of virology, 158(5), 955-965 (2012-12-13)
Cynomolgus macaques are widely used as an animal model in biomedical research. We have established an immortalized cynomolgus macaque fibroblast cell line (MSF-T) by transducing primary dermal fibroblasts isolated from a 13-year-old male cynomolgus macaque with a retrovirus vector expressing
Damien G Noone et al.
Kidney international, 90(1), 123-134 (2016-05-30)
Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise
The prognostic significance of Beta2 microglobulin in patients with hemophagocytic lymphohistiocytosis
Jiang T, et al.
Disease Markers, 2016 (2016)
Serum Beta-2 Microglobulin: a Possible Marker for Disease Progression in Egyptian Patients with Chronic HCV Related Liver Diseases.
Ouda SM
Asian Pacific Journal of Cancer Prevention, 16(17), 7825-7829 (2015)
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