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M7441

Sigma-Aldrich

Monoamine Oxidase B human

recombinant, expressed in baculovirus infected BTI insect cells

Synonyme(s) :

MAO-B

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About This Item

Numéro de classification (Commission des enzymes):
1.4.3.4 (BRENDA, IUBMB)
Numéro MDL:
MFCD04040933
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54

Produit recombinant

expressed in baculovirus infected BTI insect cells

Niveau de qualité

100

Forme

liquid

enzyme activity

≥1 U/mg

Conditionnement

vial of ~2.5 mg

Numéro d'accès UniProt

P27338

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... MAOB(4129)

Description générale

Monoamine Oxidase B is a mitochondrial outermembrane flavoenzyme that is a target for antidepressant and neuroprotective drugs.

Application

Drugs that inhibit monoamine oxidase B activity are used for the treatment of various neurological disorders including depression.
Monoamine Oxidase B has been used in a study to assess the effect of age in 23 different regions of the human brain. It has also been used in a study to determine the specific locations of monoamine oxidase in the human brain.

Actions biochimiques/physiologiques

MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.

Définition de l'unité

kynuramine deamination activity: One unit will deaminate 1 nanomole of kynuramine per minute at pH 7.4 at 37 deg C.

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Aiko Ishiki et al.
Acta neuropathologica communications, 6(1), 53-53 (2018-07-01)
Recent positron emission tomography (PET) studies have demonstrated the accumulation of tau PET tracer in the affected region of progressive supranuclear palsy (PSP) cases. To confirm the binding target of radiotracer in PSP, we performed an imaging-pathology correlation study in
K N Westlund et al.
Neuroscience, 25(2), 439-456 (1988-05-01)
Monoclonal antibodies, specific for either monoamine oxidases A or B, were used to determine the localization of monoamine oxidase in the human brain. Two distinct populations of neurons were detected by immunocytochemical staining. Neurons in regions rich in catecholamines were
The effect of age on the activity and molecular properties of human brain monoamine oxidase
Fowler, C., et al.
Journal of Neural Transmission. General Section, 49, 1-20 (1980)
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
Binda, C., et al.
Nature Structural Biology, 9, 22-26 (2001)
Dorota Łażewska et al.
Molecules (Basel, Switzerland), 26(12) (2021-07-03)
Neurodegenerative diseases, e.g., Alzheimer's disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but interconnected targets can
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